ID A0A1B8CC44_9PEZI Unreviewed; 600 AA.
AC A0A1B8CC44;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE00_07077 {ECO:0000313|EMBL:OBT44399.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT44399.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT44399.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT44399.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV454607; OBT44399.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8CC44; -.
DR STRING; 1622147.A0A1B8CC44; -.
DR OrthoDB; 4517707at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000091997}.
FT DOMAIN 15..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 189..281
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 600 AA; 65067 MW; 90864A663F1105FA CRC64;
MSSSWTPPNT AGRPVAILGA GVLGRRMALM FLAGGHNVHI RDPSADQLSA ALSYISATLP
SLTSSVVPGT AHTFSSLSEA VENAWLVIEA IPEVLSLKIS TFAELAALAP KDCVLATNSS
SYKSSAMIEE VHEVDRARVL NMHFFMPPAK RVVELMTCGV THHSIFPFLY EELTRINMSP
VVVKKESTGF LFNRIWAAIK RECLTVIAEG VGSPEDIDGV WTQMFNSPEG PCTLMDQVGL
DTVAHIESHY ISERGFDPSA RDFVVSEYVG KGKLGKKSPS GGLYPPQQEE VPARGLYILD
LGLTNLSAPM SSGRVLAGSI DGKTPLRTLS SSESLPDGIT TLGNRLYWTS MGPPSTNTGS
IRSSTPSGED ITTILPPGKV HTPKQITADR TNNYLYVSDR EGMRVLRFRP DGEDLTILVK
NGDCNKKEHR DDQMRWCVGI AVDPVHRLVY WSQKGPSKGG QGRIMRASLD IPKGETAETR
TDIEILFSSL PEPTDLEIDT ESETLYWCDR GELPLGNTVN CASVALGERK VAGKSELERK
LGYKIILAGL HEAIGLQIDV EGGFIYASDL GGSVYRFNID GSGKQKLYES ECAFAGIALA
//
