ID A0A1B8CQ39_9PEZI Unreviewed; 667 AA.
AC A0A1B8CQ39;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=VE00_00565 {ECO:0000313|EMBL:OBT48911.1};
OS Pseudogymnoascus sp. WSF 3629.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622147 {ECO:0000313|EMBL:OBT48911.1, ECO:0000313|Proteomes:UP000091997};
RN [1] {ECO:0000313|EMBL:OBT48911.1, ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|EMBL:OBT48911.1,
RC ECO:0000313|Proteomes:UP000091997};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSF 3629 {ECO:0000313|Proteomes:UP000091997};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; KV454567; OBT48911.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8CQ39; -.
DR STRING; 1622147.A0A1B8CQ39; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000091997; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000091997}.
FT DOMAIN 25..260
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 374..609
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 112..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 72213 MW; 917AE7B10EFD212C CRC64;
MADPVVEELN ALFAPASVNK KLEADVLSEL QSIMRIHIIP PQELFYKWES YSMKIGTDDM
KLDIETSRAL KKDIQDGLER EHRNKSNVRS VDKRVATPRN ISNAGDVFNM LDGLVPNTPR
TAPGSAASKR KINQFQTPSI SRVKQEPASS PPEFKTPYKP GEKEYGGPTV AFNDRPNAGQ
TVEILNEQLP APSPPIAPFS EPRIKLIANS DLKKLSYKPM AMKSSESSEI LDDRIDELMA
LIKTHHSLDD SAFGSAASKS VDEIVAIGRI ASDSADGKLN TASLVLETSR RMGNGLRVPL
RLGSVASFQF FPGQIVALRG INASGEEFTV SEVLEIPLLP VAASTPLGLE THIQRLRGGL
DAMDSDSAAA PLNILIGAGP YTTDDNLDFE PLHALCSEAA DTYADALILV GPFLDTEHPL
LASGDFDLPP EADSDPDTTT LKTVFKHLIS RPLQSLAAAN PSITILLIPS VRDAISAHVS
WPQEPFPRKD LGLPKQAKIV GNPMTVSINE IVTGISGQDI LSELRHEEVT GGAPQAGGIL
ARLPKYIIEQ RHFFPLYPPV DRKLLLRTGT VEGTPPGAML DVSYLKLGEM LNVRPDLLIV
PSTLPPFAKV VESVLVINPG VVARRKAAGT FARVSVGEAG LTEEERNGGQ TVAHKLYERA
RVEIVKV
//
