ID A0A1B8CXD7_9PEZI Unreviewed; 723 AA.
AC A0A1B8CXD7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE Flags: Fragment;
GN ORFNames=VE04_07646 {ECO:0000313|EMBL:OBT51513.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT51513.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT51513.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT51513.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; KV456807; OBT51513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8CXD7; -.
DR STRING; 1622150.A0A1B8CXD7; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157}.
FT DOMAIN 72..243
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 245..340
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 342..628
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
FT DOMAIN 639..715
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000259|Pfam:PF16353"
FT NON_TER 723
FT /evidence="ECO:0000313|EMBL:OBT51513.1"
SQ SEQUENCE 723 AA; 82231 MW; 67CBDCF2D3FA00BF CRC64;
MSNSMESVVI PEASHEMLGL GEEKSHPPIT KPDWSNLSVL HKNTLPPRGT FHIYPSESAA
VTRDVTKSRT LSLSGTWKFH LTPSPFSPDA EEFHAFNFDT SKWSDIAVPG MWQLQGHGKG
PQYTNLNYPW PVDPPNVPFD ENETGHYVRD FEVPKSWMEE GEQLRVRFEG VDSGFHVWVN
GREVGYSQGA RNPSEWDVTE LMKEGKNRIA VRVYQRCDGS YLEDQDQWWL SGIFRDVNLF
AFPKVHVKDF KVETILKNDY ENAVLFLRVE LSEPAAIKVK LLDDDLKPLK TAEQTSPLST
VFFEIPMEKL HLWTAETPYL YKLVISVGEK QVISQRVGFR QVEIKDGLLK VNGKRIVIRG
VNRHEHHPDH GRAVPYDFLR RDLLMMKTHN INAIRTSHYI NDPRLYDLAD ELGLWILDEA
DLECHGMGEL GTDFASWTSD NPEWKDAYVD RARQMVMRDK NHPSIIIWSL GNESAYGRNH
RSMYEFIKSY DKTRPVHYEA DFNAESTDVF SRMYHSVEQL IEFVTTNKEA KPMVLCEYVH
AMGNGPGGIK EYVDAFYKYP RLQGGFVWEW ANHGLRTKTA DGEEYYGYGG DFGDLPDDGH
FVVDGLVYSD HTPTPGLTEY KKAIEPIQVL SEGSTPQKIK IINRYDFATL DHLKCEYSIV
SDGVATSTSS GGGYTKGYQT GDDGGESYIE LTFTLAKATT WAPAGFELAF GQIQIHAPSP
LPP
//
