ID A0A1B8D4T2_9PEZI Unreviewed; 857 AA.
AC A0A1B8D4T2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE04_06698 {ECO:0000313|EMBL:OBT54114.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54114.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT54114.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT54114.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV456337; OBT54114.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8D4T2; -.
DR STRING; 1622150.A0A1B8D4T2; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157}.
FT DOMAIN 2..437
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 218..295
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 471..669
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 167..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 94723 MW; 3F23C57F6892B8C6 CRC64;
MPGFADSFWS ADYAGGKYSR LGVLFGKLQQ GVLENQQVLT IARMRAEAED LYGMRLGDIG
PATDKMTGGF TRDDGASLKK AYDGVRSEME EASKNHRRIA SSIRELVVNP FSRWCDAHEN
RVQSSQDDLQ SRIKYHDKQA ESVRKLRSNY FNKCRLVEDI EEENKLAFQD PSGPEGSPKG
KQNIPEIKVE ENDEDDEPLK IGDEIYQPEQ VKKMLEHALN TVALGDTKVP ILGTYQNTTS
GAGIVEYLQK HLGATTISHA ERVGQDLVDH GFLRLIGNVG NTFANSSKMF YQWRPRAFQY
AGVPEKKQTL NRTFSLAPNS DFAESPVVGA VGEYLSGWSL VNQHPNETPA QRLRREAAEA
DERYKASVRK LDLLRCQLEE AIIDHLKFME RCELDRLKAI KSVVLDFSGA ISNAIPSLQS
TVDKMMLYQE TVQPLGDLRY LLENYRTGGF APKVQIYDNY YNSADEQTFG VDLEARARAD
KKRVPNAITS ILTFLDNHYP DLEGDEARRG IWLVDVPLQI THRLRDEINN AKPVPMETLQ
RYDIPVVASV LKLYLLELPD SLVSSHVYEI VKTIYNTPAS ESTDSARVSV LQNTLIQLRL
SNIATLDALM THFTRLIELT SADEAYTAAL AQTLDAGVPR PRAENSLTLE EKHSYRLIRD
LFVHKSQIFS ELKRASSLSH SANNANNNRP RAISTDESNR KANMEARTRA ILAAGGSRSR
APARRRARTS PTLTSETRNS RGSLGSTVNR ASLDIPGSID SISTGPDSHS ASSALQQATN
GVSDFNSFGA GTADVGADEV GVEKRNSLGR PGHPVVGRLA TARKPPASSA LNRLSVGGGG
KLEQPAGVSL TDKAMDD
//
