ID A0A1B8D555_9PEZI Unreviewed; 1190 AA.
AC A0A1B8D555;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE04_06512 {ECO:0000313|EMBL:OBT54200.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54200.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT54200.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT54200.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV456327; OBT54200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8D555; -.
DR STRING; 1622150.A0A1B8D555; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd04041; C2A_fungal; 1.
DR CDD; cd04052; C2B_Tricalbin-like; 1.
DR CDD; cd21676; SMP_Mug190; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037767; C2A_Mug190-like.
DR InterPro; IPR037765; C2B_Tricalbin.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR47348; MEIOTICALLY UP-REGULATED GENE 190 PROTEIN; 1.
DR PANTHER; PTHR47348:SF3; MEIOTICALLY UP-REGULATED GENE 190 PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51847; SMP; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..466
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 464..593
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 653..797
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 132680 MW; 92AFEC8B6513F724 CRC64;
MSSGDAKFGP GGHYSARNPV PTIQRFVENL DKDKKARDAQ MIAQQQAQSG EVQPHKNKRT
SEPTSSRKTV TDPTTGRQVQ IEDVDEHFMD AALNPKLSVP NANLGKPTTM QSHHTQSGEE
YKYAQDVTAP PDPIHPGSTS DVPIKGELTN ILFHPTPSIS YEPMFEALEK RTEILCIGVL
VGIVILGKMF GGALYGLIPL GMCVSSGIFL WMKAVLRAGR DQEWASEQER GETAVANLIP
ESVEWMNTLL GVVWGLIDPE MFASVADTLE DVMQASVPGI IENVRVAEIN QGSNPIRILS
LRALPDHHVE ELKDDIHRQN VEKKDPQEVA ADEEGGDYYN IECSFAYHAK PTGKGVSSKA
KNMHMELVFY LGIKGLFGVP LPIWVELQGL VGTVRLRLQM SPEPPFLKAL TFTLMGLPKV
QAGCMPMLES NVNILNLPLI SKFVNYAIGA AAAEYVAPKS MTLDMAKMLQ GDDIQKDVEA
LGILWIRIHK ATGLSKQDRR GSEGGGSDPY ITVSFSKYGK PMYCTRVIQD DLNPVWEETC
ALLVTPDLIK ADEQLSMELW DSDRSTADDV VGKVEISMQK MIQHPGKMYP QVSKLRGTKA
ESSMPGELMW EVGYFSKPQM RPALRTHGKD INLPDSLKDN PALQDEKGSL DNPEEDAVVH
TPPDPLWPSG VCSVIIHQIV NLELENTQGS NGNRKGREFE PAVESGETKE EEGKRLPSSY
CTILYNDELV YRTRAKVVSS KPIFNAGTER FMRDWRSGII TVTVRDQRMR QHDPILGVVP
LKLSDILQTS SQVTRWYPLD GGIGFGRIRI SLLFRSVETK LPINQLGWDV GTFEFRSPKI
IAIGYQSSAK LKMRTGGSTG RIGRSHCQKL AEGDGMFWDL ARKGGKSNVR LPVKYRYRSP
IVFEFRKSGS RSVDAYAVIW LHHLEDNREE AINIPIWKTD KGMRLTQNYI TEENFNSIPD
IKIEEVGRLQ FRCCFKAGTD EDHAHFVCDN DTRETQETWE ACHAEGVRTT HVSKEMPPAV
QQLHDQSLTQ GRDVLSQADE DDKKKWLSKD GTDWSGAFGE DPSKFVDYRG ARSAQGDSYD
RRPSTGQSGR PSTGGGRSSE YTYDDEDSDD SDLGLQDATT TSRESEGPAE GGEVQTKADV
KDLHRKQRGL MQWKPMRNLQ FAKDETKFAV KKTIGKWKLD GREPGAESEY
//
