ID A0A1B8D6L4_9PEZI Unreviewed; 873 AA.
AC A0A1B8D6L4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Glutamate carboxypeptidase II {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE04_04976 {ECO:0000313|EMBL:OBT54736.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54736.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT54736.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT54736.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; KV456264; OBT54736.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8D6L4; -.
DR STRING; 1622150.A0A1B8D6L4; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF71; CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 148..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..392
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 491..675
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 744..868
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 97741 MW; 86A26F2908255234 CRC64;
MPDEKPYKYE NLPIPTYDEA TSSRSPTPAT SRPNEASNNE ERQGLLGDEA RLPVPTRRIG
YRPPPTEDDE SRRDSLDSLE FLGSDEGRDS MAAEDAEMRR EMDEMEIEEP PAEQSRWGKR
ISSISQSLHF PFKFRLPKWK FKMPEMDASI FILLARMFAL LVVVGLAYLL FMSDFFSNAS
RRMGGQMFDP GRVREWLQEQ IDSEKIRDNL EHLTAYDHLA GTQGDFALSN WIQQQFLNAG
LENVVRDRYD VYLNYPKAGG RAVEILNADG SVKWKAKLEE DNVYPEEKRQ QALAFHGHSK
SGHVKGPLIY ANFGSREDFK RLKDSGIDTK GAIALVKYYG SQGDRSLKVK AAEQAGFAGC
IIYSDPAEDG FVKGKAWPDG RFMPADGVQR GSVSLMSWVI GDVLTPGWAS VKGAKRLPVA
DNPGLNKIPS IPLAWRDAQI LLQSLKGHGQ AVPPEWKGGV PDVEWWTGDL SSPVVHLKNE
QDEVEQQPIW NVIGRIQGVE QSEKSIIIGN HRDAWAYGAA DPGSGTAILI EMARIFGELK
RHGWRPLRTI EFASWDGEEY NLIGSTEYVE NNIDKLRANG VAYINVDVAV SGQDFQASAS
PAFEEVIRVV MDRINNPVRN GSTLLQLWEE SKSKLEGLGA GSDYVAFQDI AGVSSIDIGF
SGERFPYHSV YDNFEWMEKF GDPGFLYHHM LCQVWSLLVL EMADNPILPL SMPSYATAIG
KYVEDLNQWA GSKGANQAGK PKWDIEPLRA AALKFKGDAE RYRSWETYWR NFINNNGGYE
QMDVSIIRQS YNNRASDFET LLLDLEVGGG VPGREQFKHV LFAPQAWSGY DESFFPAIRD
AIEAGDWKAA EKAVGTAAKL LTIASEQLVE GDL
//