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Database: UniProt
Entry: A0A1B8D6L4_9PEZI
LinkDB: A0A1B8D6L4_9PEZI
Original site: A0A1B8D6L4_9PEZI 
ID   A0A1B8D6L4_9PEZI        Unreviewed;       873 AA.
AC   A0A1B8D6L4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Glutamate carboxypeptidase II {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VE04_04976 {ECO:0000313|EMBL:OBT54736.1};
OS   Pseudogymnoascus sp. 24MN13.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54736.1, ECO:0000313|Proteomes:UP000092157};
RN   [1] {ECO:0000313|EMBL:OBT54736.1, ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|EMBL:OBT54736.1,
RC   ECO:0000313|Proteomes:UP000092157};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; KV456264; OBT54736.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8D6L4; -.
DR   STRING; 1622150.A0A1B8D6L4; -.
DR   Proteomes; UP000092157; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF71; CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        148..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          304..392
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          491..675
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          744..868
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  97741 MW;  86A26F2908255234 CRC64;
     MPDEKPYKYE NLPIPTYDEA TSSRSPTPAT SRPNEASNNE ERQGLLGDEA RLPVPTRRIG
     YRPPPTEDDE SRRDSLDSLE FLGSDEGRDS MAAEDAEMRR EMDEMEIEEP PAEQSRWGKR
     ISSISQSLHF PFKFRLPKWK FKMPEMDASI FILLARMFAL LVVVGLAYLL FMSDFFSNAS
     RRMGGQMFDP GRVREWLQEQ IDSEKIRDNL EHLTAYDHLA GTQGDFALSN WIQQQFLNAG
     LENVVRDRYD VYLNYPKAGG RAVEILNADG SVKWKAKLEE DNVYPEEKRQ QALAFHGHSK
     SGHVKGPLIY ANFGSREDFK RLKDSGIDTK GAIALVKYYG SQGDRSLKVK AAEQAGFAGC
     IIYSDPAEDG FVKGKAWPDG RFMPADGVQR GSVSLMSWVI GDVLTPGWAS VKGAKRLPVA
     DNPGLNKIPS IPLAWRDAQI LLQSLKGHGQ AVPPEWKGGV PDVEWWTGDL SSPVVHLKNE
     QDEVEQQPIW NVIGRIQGVE QSEKSIIIGN HRDAWAYGAA DPGSGTAILI EMARIFGELK
     RHGWRPLRTI EFASWDGEEY NLIGSTEYVE NNIDKLRANG VAYINVDVAV SGQDFQASAS
     PAFEEVIRVV MDRINNPVRN GSTLLQLWEE SKSKLEGLGA GSDYVAFQDI AGVSSIDIGF
     SGERFPYHSV YDNFEWMEKF GDPGFLYHHM LCQVWSLLVL EMADNPILPL SMPSYATAIG
     KYVEDLNQWA GSKGANQAGK PKWDIEPLRA AALKFKGDAE RYRSWETYWR NFINNNGGYE
     QMDVSIIRQS YNNRASDFET LLLDLEVGGG VPGREQFKHV LFAPQAWSGY DESFFPAIRD
     AIEAGDWKAA EKAVGTAAKL LTIASEQLVE GDL
//
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