ID   A0A1B8D6Q5_9PEZI        Unreviewed;       716 AA.
AC   A0A1B8D6Q5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Transketolase-like pyrimidine-binding domain-containing protein {ECO:0000259|SMART:SM00861};
GN   ORFNames=VE04_03462 {ECO:0000313|EMBL:OBT54776.1};
OS   Pseudogymnoascus sp. 24MN13.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54776.1, ECO:0000313|Proteomes:UP000092157};
RN   [1] {ECO:0000313|EMBL:OBT54776.1, ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|EMBL:OBT54776.1,
RC   ECO:0000313|Proteomes:UP000092157};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|ARBA:ARBA00007131}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KV456260; OBT54776.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8D6Q5; -.
DR   STRING; 1622150.A0A1B8D6Q5; -.
DR   Proteomes; UP000092157; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR049557; Transketolase_CS.
DR   InterPro; IPR033247; Transketolase_fam.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR   PANTHER; PTHR43522:SF6; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          383..566
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   716 AA;  78619 MW;  EF4B4CF813389B72 CRC64;
     MAPLATTNGA VDAGLIWNQE RIPTPNVSTK ECDLIIKEFR LLVADLCQQF EGGHPGGAIG
     MAAIGIALWK YTMKYAPHSP DYFNRDRFVL SNGHCCLFQY CFLHLTGYRD MTLEQLKSYH
     SDRVDGLCPG HPEIELEGIE VTTGPLGQGI ANAVGLAIAS KHLAATYNKP GYDVVSNHTW
     CMIGDACLQE GVALEAISFA GHHKLDNLTV MYDNNQVTCD GSVDLTNTED VNAKMRSCGW
     EVIDVEDGCF AIQDIVDALC HARETKSEKP TFINIRTIIG VDSAVAGDAK AHGAAFGTEN
     VAKMKTAYGF DPTEKFVISQ KTRNFFEEIP ERGEKLVADW NALVTGYTRK YPELATEFKQ
     RVGGQLPENW KDHIPASFPA SSTPSRKSSG LVFNPIAEAV NSFMVGSADL SPSVNMTWPN
     KVDFQHPELK TACGINGNYA GRYVHYGIRE HAMAAMSNGM AAFAPQTIIP VTSTFFMFYL
     YAAPAVRMGA LQKLQVIHVA THDSIGTGED GPTHQPVELA ALYRTMPDLL YIRPGDSEEV
     AGAWALAIES KNAPSIISLS RHALPQQTTT RRDKVAFGAY VLKEILDADI TIIGVGSELN
     IADSLAAQLT ITHSLKVRVV SFPCHHMFMK QSKEYQRSVL GRHMGIPAIA VEAYMSTGWE
     RWADAVFCLK SFGHSLPGHA AYKHFGFTPE QMLPKVLKYL EDIKQDALLG REFVEL
//