ID A0A1B8D780_9PEZI Unreviewed; 986 AA.
AC A0A1B8D780;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=116 kDa U5 small nuclear ribonucleoprotein component {ECO:0000256|ARBA:ARBA00018774};
DE AltName: Full=U5 snRNP-specific protein, 116 kDa {ECO:0000256|ARBA:ARBA00031432};
GN ORFNames=VE04_04518 {ECO:0000313|EMBL:OBT54965.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT54965.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT54965.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT54965.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV456240; OBT54965.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8D780; -.
DR STRING; 1622150.A0A1B8D780; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW Ribonucleoprotein {ECO:0000313|EMBL:OBT54965.1};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 133..423
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 109663 MW; 8EB53EFB9B06D973 CRC64;
MDDLYDEFGN FIGEAEESED DSQHGIDASA YVYDQEYPEE EEAPEVTGQE LMEIDEDGPS
NAVILHEDKQ YYPTAQQVYG EDVETMVQEE DAQPLTQPII APVEVKKFLL EEADLPPVHF
DRPFMADLMN FPDQVRNVAF AGHLHHGKTA LMDMLVLETH DIADRLENRV GKARDEQLRY
TDTSIMERDR GLSIKAAPMS LVLQNTKGKS HLLNIIDTPG HVNFVDEVAA SLRLVDGVVL
EVDVVEGVQV NTEQIIKYAV LEGLPLVLVV NKLDRLILEL KLPPTDAYFK LKHVIEEVNT
AIENALPGQG ETRRLSPEKG NVLFACSGMQ WCFTLQSFAR MYADTYPGIS ATEFARRLWG
DVFFNPTKRS FTRKGVEERS KRSFVNFILE PIYKLYSHTI SESPEDLKET LATLNIHLKP
SQYKADAKVL LNLVCAQFFG PANGFVDMVV EHIPSPVEGA QKKLQQYYTG PLDSKVAESM
AKCDQDGPLV VQISKLFNTS DASGFNAFGR VLSGTAKPGQ QVRVLGEGYS VHDEEDMAIA
TISDVWIAET RYNIPTDGIP AGNWCLLGGV DNSIVKSSTL VPLKLEDDEE AYIFKPIKQL
TESVFKVAVE PINPSELPKM LDGLRKINKS YPLITTKVEE SGEHVILGTG ELYMDCVLYD
LRRLYAEMEI KVSDPVTRFC ETVVETSAIK CYALSPNKKV KITMVAEPLD SGIAEDIESG
KVSIRDPVRK TGKFFEENYG WDLLASRSIW AFGPDDIGPN ILQDDTLPSE VDKKLLATVR
DTIRQGFSWG TREGPLRADP LRNTKFKITD ATLAASPIFR GGGQIIPTSR RAVYSSFLMA
SPRLMEPVYS VAMTGPADSV SALYTVLARR RGHVLSDGPI AGTPLYRCQG LIPVIDSFGF
ETDLRIHTQG QAAVSLVFER WSIVPGDPLD REVTLRPLEP ASVQGTARDF VLKTRRRKGL
SEDVSVAKFL EPELFSSLKE SGLLDG
//
