GenomeNet

Database: UniProt
Entry: A0A1B8DCD2_9PEZI
LinkDB: A0A1B8DCD2_9PEZI
Original site: A0A1B8DCD2_9PEZI 
ID   A0A1B8DCD2_9PEZI        Unreviewed;      1729 AA.
AC   A0A1B8DCD2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   03-JUL-2019, entry version 18.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=VE04_02778 {ECO:0000313|EMBL:OBT56652.1};
OS   Pseudogymnoascus sp. 24MN13.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT56652.1, ECO:0000313|Proteomes:UP000092157};
RN   [1] {ECO:0000313|EMBL:OBT56652.1, ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|EMBL:OBT56652.1,
RC   ECO:0000313|Proteomes:UP000092157};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus
RT   causing white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen
RT   causing white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KV456100; OBT56652.1; -; Genomic_DNA.
DR   EnsemblFungi; OBT56652; OBT56652; VE04_02778.
DR   Proteomes; UP000092157; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092157};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       49    247       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      902   1084       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1152   1584       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1625   1696       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      454    478       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8DCD2}.
FT   REGION      525    544       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8DCD2}.
FT   REGION      849    879       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8DCD2}.
FT   COILED     1650   1670       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    525    543       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8DCD2}.
FT   COMPBIAS    858    879       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8DCD2}.
SQ   SEQUENCE   1729 AA;  196908 MW;  59DA3B4410B45A90 CRC64;
     MDLFRVRLNC IDHYQAFPTR FDPQLRRDVA PSEITSEPKV PVIRVFGTTE TGQKVCAHIH
     GAFPYLYIDY NGQITSDEVG AYIHRLHLSI DHALAVSYRR GVYDRRTRFI ARITLVKGVP
     FYGYHVGYQY YLKIYALDPV VMTRLADLLR QGAIMKRVFQ PYEAHLQFIM QWMTDYNLYG
     CGYIDSRQVY FRGPVPKYEE LDKLSHLWHD RSIPAEFVTS EAKLPRASHC SLEVDILVQD
     ILNRQEISQR PLHHDFIERS NPLPPDQKLV HSMSELWRDE TKRRKAKMKV AEPGSNTFPP
     EVLISMSAGP RSSQKGRWVH EEEYMELVHT RIQEERAKSD GCNISFDTYI KPKPDEDDIN
     TTFQSVEDLY PENLGPILGL LPEKLPVLPK EDFIAGDIEV DENCIFNISD DNEFPYDSDD
     GLLCDIEQSQ EKKDNIISPP IVATSSFKAE HTVDHDSVPL NNSPRVHKSE DLCSSIEPDD
     REHPIKARIY EPRREATPIS ALELASSNAT AEDLLRDMKV ATPLGGSKTT SLKRSTSLIP
     SDEGYNKRSK FDSAIAPIQS TSSAAESRPI VNHQPLSGYD IIAKNGSCYI RKLGNILSER
     DQHSLPMLPT VNGLSHTLNE GKRLVHRNVD SGKLDPQPLP SSEPINQQEI DTVFRRSQYR
     SSQDQGDTSF NENKNLLAVT SRSIQTQLES EAHRIASPSE QQLKIVSSIT WDLRNTNWVA
     QSKPVAAFAK SPPLKETVIP SLHPPVIYQD PYYGNELDVP ERPTEWAGKE FKLESLTVPF
     LPDFDKTGSS AASLGEKPAI VYNKLSENHV YEHRQRRCRL RVWEIGKPPP AFNDVADWER
     REILAKAKSR ALKSGGQPGT KPENSAHSQI EGPTQTNKHG FQYTQPHKTQ PHKTSTMQNN
     VQYMSVMSLE VHINTRGDLA PNPQEDEIQC VFWNLQLSEE HPDNLGTGGV SHAGIVAVSE
     DGQTARNIAK QTPIQVIEES SELDLLVRIV EIVRTNDPDI LTGYEVHNCS WGYLVERAKL
     KYEYDLCEEL SRMRTHSRGY SEKDSDKWGS RHTSAISVTG RHMINIWRAM RNELNLLQYT
     MENVVFHLLH RRIPHYAWRD LTMWYTSGKF ADLAKVIEYY LRRVQLNLAI LDQNELITRT
     SEQARLLGVD FFSVLSRGSQ FKVESLMFRI AKPENFVLVS PSRKQVGAQN ALECLPLVME
     PQSAFYTSPL LVLDFQSLYP SVMIAYNYCY STFLGRIVNW RGGTGKMGFT EYKRQDRLLE
     LLKDFINISP NGMMYTKPEI RKSLLAKMLG EILETRVMVK SGMKFDVNDK TTQKLLNNRQ
     LALKLIANVT YGYTSASFSG RMPCVEIADS IVQTARETLE KAIALVHSVK RWGAEVVYGD
     TDSIFIYLKG RTKDQAFDIG NEIAERVTNM NPRPVKLKFE KVYLPCVLLA KKRYVGFQYE
     KKDQQEPKFD AKGIETVRRD GTPAEQKIEE KALKILFRSA DLSQVKGYFQ AQCEKIMTGS
     VSIQDFCFAK EVRLGTYSDK GPPPPGALIS IKRMLEDHRV EPQHGERVPY VVITGAPGAR
     LIDRCVAPET LLQSDHNELD SDWYDEMPKV QRVRRVDFGP QLTGQPADVP FNKKTLESYM
     KSSSCLVCRD KLESNTGICP TCLGNRPSSI LALQTRLTAM ERKYQELERV CRSCSNISWT
     DEVMCDSKDC PVFYSRVKEK ARLTTERKVA GRLMERLQGD SGGHEDLEW
//
DBGET integrated database retrieval system