ID A0A1B8DDN3_9PEZI Unreviewed; 785 AA.
AC A0A1B8DDN3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN ORFNames=VE04_03171 {ECO:0000313|EMBL:OBT57169.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT57169.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT57169.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT57169.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
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DR EMBL; KV456064; OBT57169.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8DDN3; -.
DR STRING; 1622150.A0A1B8DDN3; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF2; VACUOLAR TRANSPORTER CHAPERONE 2-RELATED; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 667..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..148
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 186..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 88874 MW; 448A16374F759CF5 CRC64;
MRFGQTLANS VHEPWKEQYL DYAKLKRLLR EDGTGGDNKP WTEDDESRFC EEILNTQLGK
VAAFQESTFQ KLEERANDVS ERLKDLAPQV ADPDDIAKFK EIKNELDSIT NEANQLKKYS
ALNYTGFLKI VKKHDRKRGN KYKVRPMLQI NLSKRPFNSE QAYTPMINKL SVMYFIVRQN
LEDRADKGLP NIGDKTTAST ADMPPQPHPQ NREKYMAYKF WVHPDNLLEV KTYILRRLPV
LVYSEQSANQ ADASQGDPTI TSLYFDNSQF GLYSQKVDGT VDASSLRVRW YGKLTDKPEL
LLEQKTIYDD GNSEEKRFPI KEKYVQPFIT GEYKMGKHVE KLERQGQPEE KVADYQRSVN
EIQEFIKERN LHPVVRANYT RTAFQKPLDD RVRISIDTEL AFIREDSLDP DRPCRNPDSW
HRTDIDNTQM EFPFPNVNQG EISRFPYAVL EIKVKENSGK KSPQWVEDLM ASHLVHKAPR
FSKFVHGVAS LFEDYVNSLP FWLSDVETDI RKDPHDAFAE EELAKAQKAE GELLVGSYMA
SASNRKDSYK AAVGSPLGKS YMTDRLALEA ATKSRAMADA ASKGKGKGRA QDNDSGDQDI
GTISGGYGTT SSVFPSFSLS RYAQSRRQHK AALPPGVTKP GVLIKDSGPL QVEPKVWLAN
ERTFLKWQHI CILLGALAVS LYSAAGENKL AEYMGIAYII IAAFAGFWGY YIHFVRRNMI
IARSGKDFDN FVGPLVVSFA LLVALLLNFG FKYHAALERL GQNGQGINGT ASSSQIVDNG
VHSEL
//
