GenomeNet

Database: UniProt
Entry: A0A1B8DE60_9PEZI
LinkDB: A0A1B8DE60_9PEZI
Original site: A0A1B8DE60_9PEZI 
ID   A0A1B8DE60_9PEZI        Unreviewed;       487 AA.
AC   A0A1B8DE60;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=proton-translocating NAD(P)(+) transhydrogenase {ECO:0000256|ARBA:ARBA00012943};
DE            EC=7.1.1.1 {ECO:0000256|ARBA:ARBA00012943};
GN   ORFNames=VE04_02326 {ECO:0000313|EMBL:OBT57283.1};
OS   Pseudogymnoascus sp. 24MN13.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT57283.1, ECO:0000313|Proteomes:UP000092157};
RN   [1] {ECO:0000313|EMBL:OBT57283.1, ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|EMBL:OBT57283.1,
RC   ECO:0000313|Proteomes:UP000092157};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC         Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000006};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KV456056; OBT57283.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8DE60; -.
DR   STRING; 1622150.A0A1B8DE60; -.
DR   Proteomes; UP000092157; Unassembled WGS sequence.
DR   GO; GO:0008746; F:NAD(P)+ transhydrogenase activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   CDD; cd05304; Rubrum_tdh; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   NCBIfam; TIGR00561; pntA; 1.
DR   PANTHER; PTHR10160; NAD(P) TRANSHYDROGENASE; 1.
DR   PANTHER; PTHR10160:SF19; PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT   DOMAIN          69..208
FT                   /note="Alanine dehydrogenase/pyridine nucleotide
FT                   transhydrogenase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01003"
FT   DOMAIN          217..381
FT                   /note="Alanine dehydrogenase/pyridine nucleotide
FT                   transhydrogenase NAD(H)-binding"
FT                   /evidence="ECO:0000259|SMART:SM01002"
FT   REGION          39..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  52384 MW;  98F6172B4B496AB3 CRC64;
     MITPSTRLCG ALANHTAWLS QPTVTTLNRS KLRLYHSTTR LHEEKKPSEA EPEPEAPVKS
     IPYSELTIGV PTEVVPGERR RVMVEHGAGF EAQFPIHDYE AAGATLGNSR NVWTESDIVL
     KVRPPRLTAG NPTWANEEPQ FTSHVNNFVD GFKPGSVIIS MLQPSLDRNR PVVDMMAKKG
     LTSFAMDMIP RISRAQTFDA LSSMANIAGY KAVLEASNHF GRFMTGQTTA AGKIPPCKVL
     VIGAGVAGLS AIVTARRMGA IVRGFDTRSA AREQVQSLGA EFIEVDMEED GSGGGGYAKV
     MSKEFIAAEM KLFLEQCKEV DIVITTALIP GKLAPTLITE EMVSAMKPGS VVVDLAAEAG
     GNCEITVPGE LVTHKGVTVI GYTDFPSRLP TQSSTLYSNN ITKFLLSMSP KEKHFGIDLN
     DEVVRRSIVT YNGEFLPALA PLAPPPAAAP KAAEVKEEVL AVTPWQKASR EVMTVTGVLG
     AVLVVES
//
DBGET integrated database retrieval system