ID A0A1B8DJZ1_9PEZI Unreviewed; 987 AA.
AC A0A1B8DJZ1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=VE04_00602 {ECO:0000313|EMBL:OBT59421.1};
OS Pseudogymnoascus sp. 24MN13.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622150 {ECO:0000313|EMBL:OBT59421.1, ECO:0000313|Proteomes:UP000092157};
RN [1] {ECO:0000313|EMBL:OBT59421.1, ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|EMBL:OBT59421.1,
RC ECO:0000313|Proteomes:UP000092157};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=24MN13 {ECO:0000313|Proteomes:UP000092157};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; KV455959; OBT59421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8DJZ1; -.
DR STRING; 1622150.A0A1B8DJZ1; -.
DR Proteomes; UP000092157; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Protease {ECO:0000256|ARBA:ARBA00022825};
KW Reference proteome {ECO:0000313|Proteomes:UP000092157};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 350..426
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT DOMAIN 825..902
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 107855 MW; A41358B095C807F6 CRC64;
MTMHGSTRSK RKQHAAPLPE RPQKLHRAVN GKESVGENTP DLGSSSPIDE MEMEMEEDDG
DRVGIWQATI EEVVRNVVSI RFCQTCAFDT DPALTGEATG VVVDAERGYI LTNRHVVGSG
PFWGYVVFDN HEEAIKYMPV AALELRPDLA KVGAEIRVVG NDAGEKLSIL SGVISRLDRN
APEYGEGYSD FNTNYIQAAA AASGGSSGSP VVNIDGFAVA LQAGEASGRR RDRLLSACVE
AEASAGVLAA GPADHKRNDS VSMDAEAAKI RAEFPKETGM LVAEIVLPEG PSDTKLEEGD
ILLKVNGELL TQFVRLDDIL DSNVGQGVKL VIQRGSEDIE VELAVGDLHK ITPDRFISVA
GASLHELAQQ EVRLYAVACK GVFICEATGS FKFEGTDSGW LVQSVDHKKT PDLATFIEVM
KGIPDRSRVV VTYKHLRDLH TLNTSILYID RHWSSKMRLA VRNDNTGLWD FSDLAEALPA
LPPVPRSASF IQLDNPTHPA AAELVKSFVR VACHMPVKLD GFPRNRKWGM GVVLDAEKGL
VIISRAVVPY DFCDISITIA DSIIVDGKVV FMHPLQNYAI IKYDPSLVDA PVKSAKLSTE
QIKQGASTYF IGFNQNMRIV VAQTTVTDIT AVAIPANAGA PRYLAVHRDA ITVDTSLSGQ
CGRGVLVAED GTVHALWLTY LGERSSTTNK DSDYHLGMAT PTLLPVIKQI QAGVTPELRM
LSVEFNAIQM SQARIMGVSE SWIKNVAAAN SAHHQLFMVR KRTFERDQDS HALQEGDVIL
TLNGNIVTRV SELDVMYDSK VLDAVIVRDC VEMHVAVPTV AAHDVETDRA VNFCGAVLHR
PHLAVRQQIS KLHSEVYVSA RTRGSPAYQY GLAPTNFITA VNGVATPDLE SFIREVVRIP
DNTYFRLKCM TFDNVPWICT MKKNEHYFAT MEWIKDPSEE CGWRRISYEH GESIKGEGKE
GINEIAAESI AEDDTGAGDT EPVAVKA
//