ID A0A1B8DLX3_9PEZI Unreviewed; 711 AA.
AC A0A1B8DLX3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=VE03_10717 {ECO:0000313|EMBL:OBT60129.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT60129.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT60129.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT60129.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV455276; OBT60129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8DLX3; -.
DR STRING; 1524831.A0A1B8DLX3; -.
DR OrthoDB; 2606404at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 1.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR004429; Isopropylmalate_DH.
DR PANTHER; PTHR42979; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR42979:SF1; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR PRINTS; PR00415; ACONITASE.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 8..364
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 711 AA; 77452 MW; 1E9D6030E2FE2330 CRC64;
MAASKRFEIV LLPGDGAGPE LAKEVRRVLD KIQAIRQNIA FTITEKPFGG SAIALSGEAL
SESTLETCRR ADAVILCGCG DIKYGLEPEK ALLRLRSELG VYVNFRPIKF SSTQLYHQSP
FKLSAIEGTD ITFVRDLIGG VYYGKRQEAD TTNAIAYDTT SYSREAIQRI ARWAGSYATQ
SSPPKAVHSV DKYNVMATSR LWRSTVSDIF EKEFPNVPLN HLLVDHAAML LSSAPTQLNG
IILTENLFGD ILSDQAGAIV GSQDVLASAG LANPTRQHVA GRPGIFEPVN LKTGASAGLG
KVNPLGVIQT IIIMLDTAFG LVVEAESLES AIRKTLDPRE LIGSDSRTAD IGGSSSTAEF
TDRLLENFDF FLEAQNSAEL AAITSFMQVP LPNGTLANTG RRPMGIVEKI LTHSGIGLSK
DEVKPGDIIC IGVDWTITNE LLWAGMEKTY NQMKRPRLHR NDRFWLALDH IVDPRTNHLP
KQKALIAKAE LLQKEAKVID FLPVNTSIMH TDFTRERAQP EHIIVGSDSH TCSAGSMGAF
AVGMGAADVV MPMVTGETWI RVPEICKIHF VGKLPFGMGG KEVILYILGA MKRNTIAFQR
AVEFTGPGLA ELSMDARFAI ANMTAEFGGV GACFEADGIT AGWISKRKSR QHKSRGIYFK
PDPDAVYAET RLIDLSKVRS TIALYPNPDN VVPLAENLND KGDNVDSKED D
//
