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Database: UniProt
Entry: A0A1B8DQY5_9PEZI
LinkDB: A0A1B8DQY5_9PEZI
Original site: A0A1B8DQY5_9PEZI 
ID   A0A1B8DQY5_9PEZI        Unreviewed;       632 AA.
AC   A0A1B8DQY5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   13-SEP-2023, entry version 29.
DE   SubName: Full=Methylenetetrahydrofolate reductase {ECO:0000313|EMBL:OBT61530.1};
GN   ORFNames=VE03_08891 {ECO:0000313|EMBL:OBT61530.1};
OS   Pseudogymnoascus sp. 23342-1-I1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT61530.1, ECO:0000313|Proteomes:UP000091879};
RN   [1] {ECO:0000313|EMBL:OBT61530.1, ECO:0000313|Proteomes:UP000091879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT61530.1,
RC   ECO:0000313|Proteomes:UP000091879};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000091879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
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DR   EMBL; KV455063; OBT61530.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8DQY5; -.
DR   STRING; 1524831.A0A1B8DQY5; -.
DR   OrthoDB; 1381745at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000091879; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091879}.
SQ   SEQUENCE   632 AA;  70394 MW;  DB4C5519125653AD CRC64;
     MHIKDMLNQG EQAGKPTFSF EFFPPKTAQG VQNLYDRMDR MHGLGPSFID ITWGAGGRHA
     QLTCEMVSVA QSVYGLETCM HLTCTDMGKE KVDDALKNAY KAGCTNILAL RGDPPREKEK
     WVATDEGFQY ARDLVRYIRK TYGNHFDIGV AGYPEGCDDQ TDADLLLDHL KEKVDEGATF
     IVTQMFYDVP NFLDWVKKVR AKGINIPIIP GIMPISTYAS FLRRCNHMNA KIPPGWIEAM
     EPVKNDDAAV REIGRGLVTG MCRAILESGI NHLHFYTMNL AQATRGVLEQ LEMLPSEERP
     LKQALPWRQS LGLGRRGEDV RPIFWRNRNK SYVMRTQEWD EFPNGRWGDS RSPAFGELDA
     YGIGLKGSNE QNIKLWGQPK SVKDIANVFL RYLNADVESL PWSEAPISNE ADVIKNQLVG
     LNERGLLTIN SQPAVDGVKS SHPVYGWGPL NGYVYQKAYL ELLVAPELID ELLDRIAKDP
     EVTYYAVTKT GTLRTNAPSD APNAVTWGVF PGKEIVQPTI VETISFLAWK DEAFRLGMDW
     AHCHEASSPS RNVIQRVMET YYLVNIVHND FHHRDGLFSL FEGLSVPNID QPAEGDVAPA
     AVPTPAAAAA ATNGTKVEDV SPAIVSNVLP VA
//
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