ID A0A1B8DQY5_9PEZI Unreviewed; 632 AA.
AC A0A1B8DQY5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE SubName: Full=Methylenetetrahydrofolate reductase {ECO:0000313|EMBL:OBT61530.1};
GN ORFNames=VE03_08891 {ECO:0000313|EMBL:OBT61530.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT61530.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT61530.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT61530.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; KV455063; OBT61530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8DQY5; -.
DR STRING; 1524831.A0A1B8DQY5; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
SQ SEQUENCE 632 AA; 70394 MW; DB4C5519125653AD CRC64;
MHIKDMLNQG EQAGKPTFSF EFFPPKTAQG VQNLYDRMDR MHGLGPSFID ITWGAGGRHA
QLTCEMVSVA QSVYGLETCM HLTCTDMGKE KVDDALKNAY KAGCTNILAL RGDPPREKEK
WVATDEGFQY ARDLVRYIRK TYGNHFDIGV AGYPEGCDDQ TDADLLLDHL KEKVDEGATF
IVTQMFYDVP NFLDWVKKVR AKGINIPIIP GIMPISTYAS FLRRCNHMNA KIPPGWIEAM
EPVKNDDAAV REIGRGLVTG MCRAILESGI NHLHFYTMNL AQATRGVLEQ LEMLPSEERP
LKQALPWRQS LGLGRRGEDV RPIFWRNRNK SYVMRTQEWD EFPNGRWGDS RSPAFGELDA
YGIGLKGSNE QNIKLWGQPK SVKDIANVFL RYLNADVESL PWSEAPISNE ADVIKNQLVG
LNERGLLTIN SQPAVDGVKS SHPVYGWGPL NGYVYQKAYL ELLVAPELID ELLDRIAKDP
EVTYYAVTKT GTLRTNAPSD APNAVTWGVF PGKEIVQPTI VETISFLAWK DEAFRLGMDW
AHCHEASSPS RNVIQRVMET YYLVNIVHND FHHRDGLFSL FEGLSVPNID QPAEGDVAPA
AVPTPAAAAA ATNGTKVEDV SPAIVSNVLP VA
//