ID A0A1B8DVP2_9PEZI Unreviewed; 357 AA.
AC A0A1B8DVP2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Opine dehydrogenase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE03_08168 {ECO:0000313|EMBL:OBT63007.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT63007.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT63007.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT63007.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate
CC + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642,
CC ChEBI:CHEBI:57945; EC=1.1.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001662};
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DR EMBL; KV455031; OBT63007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8DVP2; -.
DR OrthoDB; 2230586at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003421; Opine_DH.
DR PANTHER; PTHR38015; BLR6086 PROTEIN; 1.
DR PANTHER; PTHR38015:SF1; OCTOPINE_DH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR Pfam; PF02317; Octopine_DH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 5..105
FT /note="Glycerol-3-phosphate dehydrogenase NAD-dependent N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01210"
FT DOMAIN 177..322
FT /note="Opine dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF02317"
SQ SEQUENCE 357 AA; 39369 MW; 5D85107B4AACCB4A CRC64;
MQFRVSIVGA GPAGFALAAD LDARGTNVLV YSHPSHVRHA NYVVDNGCLR ATGKIEGSTT
LRVTFDMAEV VEFSKIIILT VPSTGQETVL REFKQFDLQQ HTVIAVPGNL FSLVADAEMK
IGSILETNLS PYSCRMKEGE LAVMGKKNLF LIAALQTYSN PSFTAEIQRI FPMKLKWCHN
VIEVCLSNIN GVFHPLMMLM NAGRIESTSG EFLLYHDGLT RSVANAMLAV DRVRLEIGEA
FGFKLDGVTQ TSNKCYNQNF TDLVDLAQNS PPHNKLKAPP TMDNRNISED VPDLLVFWCG
LAEKLGIDAS PIKAIITLAE MASGTDFMKT GRNLQKLNLE HLSRSELIER FGVSQTQ
//
