ID A0A1B8DYH6_9PEZI Unreviewed; 3342 AA.
AC A0A1B8DYH6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Nonribosomal Peptide Synthase (NRPS) {ECO:0000313|EMBL:OBT64153.1};
GN ORFNames=VE03_06255 {ECO:0000313|EMBL:OBT64153.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT64153.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT64153.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT64153.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV455016; OBT64153.1; -; Genomic_DNA.
DR STRING; 1524831.A0A1B8DYH6; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 7.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 1472..1548
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3259..3335
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 308..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3342 AA; 367235 MW; 2EDD49280DBCEBDA CRC64;
MRYQPRYGNG VQEVAQKVRR AEMQKKLAFD DIWAANLAVP EPIEACVHSL IKRVVWEFAS
SPAIRSWDGD LTYQQLDQVS TRLAHQLIGV GVKPRTNIAL CFEKTWLTPV VMVALMKAGA
ASIALDISQP RERLRVIADQ ISPSFILSST SNEELARQLG VAEVVVVDRR MLSEEAAMAC
SLPAVSPSDT LCIILSPDSS AGAAVTHREF SSAITYQQET LGLTHNSRVV DIESHATRIG
WYSLLVLTCG GCLCIPSLSG LRDSIESSII ALQADSVLLA PEFGRTTPEY AKISHLVRPR
HVVDVVTPSD ATSKNPFGTA NGNTANVQTS KSYTENQYAA NGATENGHTE NGCTQNGHTE
SVHTEDGYAA YESTEDGHPT NDHEKTKRET HIEHQPEAVR AVLDQGSESD NSQGYLSDKQ
DEPLNFVQHT EQVQINGNHF EIHQTPIESV CTTQEKSEVS HADSREPAIT PLSLLGLRSS
ADRDQACSHA AWLCHVQASQ VLDIMPCTPL QQGLLALTAQ QPGTYVARYV FEIGQDIDIK
TLCGAWDRVV ASNAILRTRI VSLPGLGIVQ VVIDEGVSWT ISTELDSIQG DQKGNGPPIG
LGTPLTKFTV IEKATDTPSQ FIWEIHHSLY DGFSMPLLMR EAELAYFNKP SQGLQPMTAF
IKYILDQDKA VAKSFWQKMF AGTQGSHFPP PKAGHHPRLE RQMSLSIPGL KWGHSDFTPA
TLIRAAWSVV TANGSGTDEA LFGATVTGRQ APVPGIELMA GPTIATVPIR ILLDRDATIN
QLLGSVQRQA VDMIPFEQTG LQNIAQFNDE TALGSNFQTL LVIQPADQGE SDPGRPFLDE
PAGDHNKAQG RDFSTYAIVI ECQLELDGVN LCIDFDSSVM GQEQIEHIAQ SFKYTISQLS
DSNQGNQTLR GLHDDQWGLR RIWNWNAVLP KPMEACIHDM VSERARENPS ALAVNAWDGN
LTYRQLEDLS TNLAYQLSED GVSGTIVPLL FEKSMFMPVA ALAVMKAGGA CMAMDIKQPR
ERLTAIAAQA NSPVILSSRI NESLAFQVSA GIKEVVTVGS NQSHPAPFSL PPVSPAGILY
VVLTSGTTGT PKGVLITHRN FCSAITYQQK ILGCSNTSRV LDLASYAFDV AWSNMLHTFT
AGGTLCIPSQ TELENDLPRC LEKYDVTYAD MTPSVARIVS RTALSRLNTL ILGGETVLPS
DAYLAGENTR VFNAYGPSEC TPTATLSDAT ADCIGHGAGV CIWVVEPDNP ELLAPIGSIG
ELYLEGPLVG EGYLNDPEKT ATVFVDDPVW LVRGIPGQSD RTGRRGRLYR TGDLVKYKED
GSLVILGRKD TQVKIRGQRV ELGEVEQHVL DAALPLLFAE GINADEIQVI AETIRPEGAN
NAILLAFISL GNAEERNMTE ESHSTAIRRV TDVLADRLTE VVPIYMVPTA FVPIYKLPIM
TSGKTDRRQL RAIGEAVYLQ YIKDSSLNDP AESLSDLEII LQQVWMSVLG VSSQEASVNK
PFTRLGGDSI SAMQAVSQGR LHNITFTVGD LLKAKTIRNL AALCRVTSQH VPEDEQEDER
DGEAFEISPV QQMFFDAYPE GLNHFNQSFV LELQRPVETT ALRGALETLL QRHPLLRARY
NKSSDSGRWM QAISMEADTQ SFAFAEHFVA NHDEIAKPGQ LRQESFDIKR GPLFAIDLFN
IPDKNQIVIL SAHHLVIDLV SWRIIWNDIE EYITHGKLLS QPTTSFRTWC KRQANIGRNL
SPLAVLPYPI PESQIGFWGL PLSENKYDNV EIHSKLFDID VSDGLFGGSN VSLKTEPVDI
IIGSMVHSFL QTFPERDPPA FWMEGHGRDQ SDDLPFDVSG TVGWFTTIYP LVVRLGHENS
AIEAIRMAKD NRQNIPGKGQ PYFACRYHSE SGREVFQGHD VVEVLFNYTG RYQQLEAEDG
LFMVPDYLFK VDSGISEISK TASRPSMIEI DANVDEGMFL ITFNVHRNLK HQDRIQEWIE
TFAETLRSVT QELLRSTQSF TLGDLPLLSL SYDGLDTLLT EQLPSMGIRT DAVADIYPCS
PLQEGVLLSS QKEISTYATF SVWECVPTDT ISAISPSRLE EAWKTVVSRH TILQSVFSLN
PEGNAFIQIV VPESHIRVTH LTVDHNPSEA LNRLQRPKFA ANEPEHAFTI CQSRTGEVSC
RLDANHTLVD AASMSIIVGD IIAVYDNYVL PPAPPFRDMI QYISSTPSSQ RIASWTKLLN
GVEPCEFPVL QANPEKTESE SRAIPIPVDI TSDIAGFCKT LGITRSVFLQ VAWAMTLSQL
TGKSEACFGY LASGRDSAVD SIETMVGPLA NLLVGRVDLR TPARKVLETT MEKSIEHLNI
QHTSLAEIQH QLGLSGRRLF NTSLSIQASN KAKTGPERKK GLSFKSHNGE DSHEYDLTLH
ASIEEDVIKS TVEFRAPYVS QNAAQEAVTT FIKAIQYLLD TNINDKNVPS LEHSLVSSFF
KHVVGTDEQL TRSFWKTHFA NIQGCHFPPV KAATYRPWPN RQVRQSLQGL KWANRGGFEV
ATILRASWSI LATRILGSNE ALFGVTSNDD KIIVPARILL NADNSIAEFL QEVQRQAYEV
APFERTGLRR IRLINDESSL GCDIQMLLHV VDHSYRVAGN QPGDIGETEE CWQESLNSCA
MIVETQVQAN RTDLCIRFDS SVIGELQVTR ITNQFEHILH QLLGLDMREQ KIRTLAVISP
RDVRDIWTWN TTVADPVKAC VHHWIIQRAR EQPLAPAISA WDGDLTYGQL LELSTNLSYE
LVKIGVGHGS IVPLCFEKSM WMPVAALAVI QTGAAAVALD PASQPEERIR TITKHVKATV
ILSSVENSGL AHRLGINEVV IVGRDQLSDQ TTSQTDKTPG PVPERYLGLP SVDPSQLLCV
IFTSGSTGAP KGVKLLHKNY SSAIAYQRDA LGYVKGARVL DFSSYAFDVV WANLLNTLTA
GGCLCIPSSD ERQNNLSECF VKYNVTMVDL PPSLARHTAG LSSLSTLVLG GEAVLPTDAY
LAGDKTRVVN AYGPAECTPS AAILDLSAAS EVGLGRGVGV CTWVVEPDNP DILASIGAVG
ELWLEGPTVG DGYLDDPVKT AAAFVQDPAW LLRGVPGGRP GRRGRVYRTG DLVRYRDDGS
LLFIGRKDTQ VKIRGQRVEL EEVEHHLQQA LSSKAAGIQV FAEPIQPRGT ENKILAAFIT
LDSSGEEHDS KVKQVTIGVN DHLSEVLPLF MIPTVYIPLQ NIPRSITGKI DRRQLREIGS
SLTAKDIAML SRLDGERRAP ESDMERLIQR LWAEVLQIDL DSISADDSFI RMGGDSIGAI
RLVGVARQNA LSLTIRDVFQ NPILRDLATV CAQGSTGSVV GK
//
