ID A0A1B8DYM0_9PEZI Unreviewed; 2312 AA.
AC A0A1B8DYM0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN ORFNames=VE03_06845 {ECO:0000313|EMBL:OBT64221.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT64221.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT64221.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT64221.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC2 family.
CC {ECO:0000256|ARBA:ARBA00007857}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV455015; OBT64221.1; -; Genomic_DNA.
DR STRING; 1524831.A0A1B8DYM0; -.
DR OrthoDB; 179356at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0000347; C:THO complex; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR040007; Tho2.
DR InterPro; IPR021418; THO_THOC2_C.
DR InterPro; IPR021726; THO_THOC2_N.
DR InterPro; IPR032302; THOC2_N.
DR PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR Pfam; PF11262; Tho2; 1.
DR Pfam; PF11732; Thoc2; 1.
DR Pfam; PF16134; THOC2_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 54..780
FT /note="THO complex subunit 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16134"
FT DOMAIN 782..858
FT /note="THO complex subunitTHOC2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11732"
FT DOMAIN 1129..1435
FT /note="THO complex subunitTHOC2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11262"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..2312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1152..1219
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1560
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1593
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1627..1683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1971..2021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2035..2052
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2066..2082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2114..2129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2130..2197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2206..2229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2312 AA; 254294 MW; 782A4280D354691D CRC64;
MSPPPRPTPT PTPTPSQQQP QPVALTPTPF VFTPAKSATP EPMKDPSPYD YSHVTNERIA
AWTASGRQEI VAAGAQSLDD LDILDLSTIF QELIRSGIDG RLSPADAGSV VRDIVQPDTA
PENQQDDKID GASLFLDSLS IVTDNEPYQP RLRKLVAATG ISPVIMRQML DTQLLQNLEL
TRDTFFKAGI RQVTNLLYRQ ANHNLLREET EGYSKLVTEL FTTSSSEPPT SEVVEETFER
IKGLIGTFDL DAGRVLDVTM DVFAAVLIKH YRFFIKLLRV SSWWPRDNIL PGVAIENADL
PKWALPGASG VMPADNEKKD DDCDKDARDE EFWVRAREIG IDAFYELGGR RSVDPKTKER
LAASKANTDD QSSADRQWIE ATGTFPPLGN QVAAQLLGFK LRFYTSPARE KDDILPANLM
YLAALLIKIG FISLRDLYPH LYPLDEDMEA LRVKKMKEIA EKEKLNRPGG GAANALMTAG
ALADDTLPGG GRMRDVPGSK PDASAGAPVE TEENKDKLPE PDEQKVVLLV NLLTIGAIPE
SLFILGRFPW ILEAYPEVLD RLHRILHHSV DKVFQATKPS NADEVVLPMK KLSDQDQSRV
PKGEVRRIEP GPRKILRWPF PAKADVGDGL TYKFYWDEWA DSIPVCQTVD DIFTLCSTLL
NYSGVNIGKD CALLSKLASI GNQSLSKDTS EANLARWQDL LKRLLVPALS HTSANTNVVN
EIYDMLRYYP APLRYNIYAE WFEGQTSRLP AMTTVFTRAR LETLSTMKRI SKTNLTAMAR
ALAKTAYANP GIVFKVALDQ IESYSNLTEV VVECARYFTD LGYDVLIWSL MSSLGGKTRS
RTRDDSALLT SKWLIALSNF SGKVFKRYSI MNPAPILQYV NDQLYRGNST DLIILQEFIA
QMSGVVPDTD FTDPQLLAMT GGEVLRRQTL ISLQDRRFES VKTAKRLMKS LTETRLAGQL
LISIAQHRQA AIFSVPEDEA HIKYLSTMVD DAQRILTQFN DLLRSNLTVE EFDNLVPDTC
ELMVDFGLDP ALAFAIGRPS FAYKMAGIGA VELPKEVTEA NGVPAVIDID GDVGMDATSS
DDDVDMIKTP EAGTTDNAVE SAPTSEDPWL DVLAPLVESV RVALPDKPWG LLSPEFYVTF
WQLSLSDIQV PMDSYTIENS RLTKEMAEIM KDRSDMTRPG MIRKEEARKA VETIKEDLLN
ESKEQMSQFG RNRARLNKEK GKWFSNVNKR YDALNDTLLE ECFLPRLLLS PSDADYAFKM
VKFLHNSSTP HFRTLGLLAR LFRGNRLRSI IFSCTIREAE CFGRFLKLIL GDLARWHSSK
AIYEKEAWGT NQDLPGFAKS IHETTSKPVA LLEYEDFRRI FFGWHRNLNT ALKSCLAGSE
WMHIRNSITV LKSVVEHFPA VDFMGKAFQH ALITLAKREE GKREDLSLLA NASMPELKKR
EKKWVMPQAF AINLGESNLA NSQAKAAKGG SPQVEGKSTL KPTAPEFNPS SKISSNGKPD
RKRKAGEVED GEVDDARAAR AAAIEAAPPG AIASEANATP IPPRQGGLPK VPPTNERQTG
PPPRPDFIRG AANQDRPPSR PPSNLPTRPE VPIPQVGPER HLPARGAGRR DAHQPRADYP
PDNSRWPRDN LGHDRRSLDA RGLERPSDRP SFDRDGHRDR VDPLRRGAEF FPGDRDRNRP
PLDIRGPDLN GRPSREDLIP PSRSAPPQAD QSPAVASERL ALADPAVNPA RAALISAGSD
TARSSSPRGF RDDRGHARAP SPRRGDRHGG PDRDVDIRRD RIPGDRDAGL DGQGQGRMRP
DANQGPPFAP RDGDRPVDRS RDAFQPTVAP KRPVDLDHGR LNPAGRPGES SFGRLNPSST
PLHDVPSGPR TSYGRGGSNR QASGNMSRSD TRQQGPPRPP SPDNKPPSGP AGDRSQSGTA
NPPAVPVHPE RMRHLGQDTQ AQSTQAALAP PANAVPEGVH PSRMRGFQET PSFPGATQSP
QQTGNVRQEP SQLSTSTPSG PRGQAGPATP TSASSNVPTG PSLPPGDRVK GTIRQLAGIN
STLQQAGQTE RPKTFDRPND RVLNVRGRGS VSSSSAMPGF PSSGPSTPVA PRPDTRDGGL
GRGMGAPEPS PGDQFANRFS QNMGNDRPDA RSGSTRDSGR HERSGRSSHR TSRSHSRERS
HKENIPGPDP RAEMMGERPD FRGSGRRDGE RESSRRVSGR SGPSTPGDGR ERESRRDGRD
GDKRGDGGAA MRGEQGFRSG PGYQSQPQGG HMPSSNRGEG GRSRGSRSSR GGGDERRESR
SGRDDGSGST GKRRGEDRGG QDRGRDKRAR QA
//
