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Database: UniProt
Entry: A0A1B8E1L6_9PEZI
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ID   A0A1B8E1L6_9PEZI        Unreviewed;       991 AA.
AC   A0A1B8E1L6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=VE03_04585 {ECO:0000313|EMBL:OBT65245.1};
OS   Pseudogymnoascus sp. 23342-1-I1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT65245.1, ECO:0000313|Proteomes:UP000091879};
RN   [1] {ECO:0000313|EMBL:OBT65245.1, ECO:0000313|Proteomes:UP000091879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT65245.1,
RC   ECO:0000313|Proteomes:UP000091879};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus
RT   causing white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000091879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX   PubMed=29295979;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen
RT   causing white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; KV455004; OBT65245.1; -; Genomic_DNA.
DR   EnsemblFungi; OBT65245; OBT65245; VE03_04585.
DR   OrthoDB; 179316at2759; -.
DR   Proteomes; UP000091879; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000091879};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091879};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    991       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5008606087.
FT   DOMAIN      392    569       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   991 AA;  108462 MW;  A30A5F53AB136EDF CRC64;
     MKIATLLTAA CVAFQGTAAA AVSGKPSTFI RDYDKRDLLQ DVVTWDEHSL FIHGKRAMIF
     SGEVHPWRLP VPSLWLDLFE KIKALGYNTV SFYVDWNLLE GKQGEFRADG VFAYEPFFEA
     ATKAGIWLIA RPGPYINAEV AAGGLPGWLQ RIKGMIRTNA DDYMEATELY VASIGAIIAK
     AQITNGGPVI LYQPENEYSG GIEPALFPDG PYFQRVIDQV RKAGIVVPLI NNDAWSGGHN
     APGTGLGEVD IYGHDNYPIG FDCSDPTVWP ADGLRTDQYS TRVEISPNTP YTIPEFQGGA
     FSPWGGWPIE KCAELVNQEA ERVLYKNNYA AGISIMNLYM TYGGLNWGNL GHYGGFSTYD
     YGAAIKADRT ITREKYSEAK LQAQFLKASP DYLTAVPTNL STTLYTDNAN LAVTPVIGSE
     APSSFYIVRH NIYNSTETTT YSLNIKTSAG KLTVPRLGGK LTLNGRDSKV HVTDYNVGGT
     TLLYSTAEVF TWKKFDSGKV LILYGGPEEL HEASIVSTAK PTIIEGKGVT TKSIDGNVVL
     QWKTSASRRI VKIGDLSIYI LDRNSAYNYW VPDLADGSAV IVKAGYLVRT AATKGNTLQL
     TGDFNATTPF EVIGAPKSTK KLTINGQQVA IETSKSTGTW SGAVKYQRPS FNIPNLEKLE
     WKSTDALPEI QTSYDDSAWP SANKKTSTNT YRNLTTPTSL YSSDYGFHYG YLIYRGHFVA
     TGAETTITLY TQGRNAYGTS AWLNGVDLGS NAGNATVGDS NSTYTLGKLS KGKKYVLTML
     MDNLGYDGNW VIGSDSMKNP NGILHYEFAG RKQSDITWKL TGNLGGEDYV DKTRGPLNEG
     GLFPERQGWH QQKPPTHGWK ASKPTTGISK AGVAFYTAEL NLNIPKGWDV PLSFTFEKTK
     PDEKFRAQLY VNGYQFGKYI NNIGPQVDFS VPQGILNYQG SNTVALTLWA QQPSGAKLEG
     LSLTAGTPIL TALENIELVP MPKYAKRAGA Y
//
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