ID A0A1B8EEP7_9PEZI Unreviewed; 1040 AA.
AC A0A1B8EEP7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=VE03_00767 {ECO:0000313|EMBL:OBT69824.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT69824.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT69824.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT69824.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; KV454976; OBT69824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8EEP7; -.
DR STRING; 1524831.A0A1B8EEP7; -.
DR OrthoDB; 6297at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IEA:UniProt.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 293..371
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 387..422
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 17..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..979
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1025
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1040
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 114820 MW; 9BA135EB9155E8BD CRC64;
MPADIRNFFG GKGAVPAPKK DKAEVPSSRR KQTRKIIDES DGDENEVKKI ATPRKAVPKK
PSNKTPPKGE ETTTSDYFAS RGSKKVAKGP PEPTKLTALS PRPKTKLPTA DFAAKKPGKD
KPQREAYKNA EDDDRGAYVD VDDPDEGDDI FAADVKTGGR RREDDDYMEI DSDKDEFVVT
KASQNGKLAP INKKRKSLSL DPDDSDEFDE PKKGLKVNEK KPPAKKPRAT AKKEVIPESA
EMQAVLDSIP TVEAPSPPSK SADGEKFNWR KAATGGGNSG PPPGAGSKEM PVGADNCLAG
LTFVFTGLLE TISREEGQEL VKKYGGKVTG APSGKTSYVV LGSDAGPSKL EKIAKLKIKT
INEDGLFALI RATSEHLTQT GGTTRAAEKA LEKQKEAEKK MKIEAEEEER QERLRAAEAE
KAARKVAESR GLAPPPNKNL PSSQLWTVKY APSKMNQICG NKGQVDKIQS WLQGWPKAHK
LGFQLPGKDG LGIYRSIVIY GPPGIGKTTA AHLASKLEGY DVIESNASDT RSKKLVESGL
QDVLNNSSLL GFFAGHEEQV DSKKKKIVLI MDEVDGMSAG DRGGVGALAK ICKKTDIPII
LICNEFRIPK MNPFRHVVAE VPFRRPTVDQ VRSRVATICH REGLKLSREA MDALIEGSNK
DIRQVVNMLS SAKLDQTAMD FDQTKSMSKQ WEKHIVLKPW DICHKLLGSG MFAPSSKSTL
NDKIELYFND HEFSYLMIQE NYLRTRPLMP PNQNMSPREQ RLKTLELADK AAESISDGDL
VDRMIHGSQQ QWSLMPVHAV FSSVRPASFM SGAVTGEMPF TTWLGNNSKH GKLSRFVKEI
QSHMRLRTSG DRHEIRQQYL PTLWTQLIKR LEIEGKDSVD EVIDLMDSYF LTRDDFDSIM
ELGVGPQRQE LVSLETQTKS TFTRLYNSRT HPMPFMKASN VVAPAKATKE MPDLEEAIEE
SDNGEALVET PDDNEDDDMD ISKDKYIKKP KVKKAAGKKP AAKKSKKTDD AEGDTQDEGK
PKKPRASKPK ATSTKAKAKK
//
