ID A0A1B8EN48_9PEZI Unreviewed; 1034 AA.
AC A0A1B8EN48;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Insulysin {ECO:0000313|EMBL:OBT72754.1};
GN ORFNames=VF21_08992 {ECO:0000313|EMBL:OBT72754.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT72754.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT72754.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT72754.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; KV458879; OBT72754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8EN48; -.
DR STRING; 1622149.A0A1B8EN48; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 54..202
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 228..407
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 414..702
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 707..888
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 118087 MW; 554995836A104729 CRC64;
MPTPSQPQTP TTLDSPLREH RQRPVERLTD KLETPSLDDR QYRVIKIASN QLEVLLVHDA
DTDKASAAMD VNVGNFSDPE DTPGMGHAVE HLLFMGTKKY PVENAYSQYL SAHSGSSNAY
TAATSTNYYF EVAAKAAESA EETDRSPLYG ALDRFAQFFI EPLFLPSTLD RELRAVDSEN
KKNLQSDQWR LHQLDKSLSN PKHPYCHFST GSLETLKIQP EAKGIDVRQE FINFHDKHYS
ANRMKLVILG REPLDVLEEW AVDLFAGVKN KDLEQNRWED EQPLGKDELL TQIFAKPVMD
SRLLELTFPF LNEEDLYESQ PSRYISHLIG HEGPGSIMSY IKGKGWANGL SAGGYAVCPG
SLGLFNCQIR LTEEGLKNYK EIVKVFFQYI SLLNESPPQE WIFEEQKGLA EVDFKFKQKS
PASKFTSKIS AVMQLPLPRE WLLSGHSRLR KFDPKAIEAG LAYLRPDNFR MSVVSQTFPG
GWDKKEKWYE TEYKYEKIPQ EFIAEIESAA SSTKASRLSQ LHLPHKNQFI PTNLDVEKKE
VKEPTRAPTL IRNDDMVRAW FKKDDTFWVP KANLFIQCKN PLPSATAENT IKSRVYAELV
RDALEEYAYD AELAGLDYSV SSYSGGLDIQ ISGYNDKLPV LLEKVLLTMR DLEVKPDRFA
IVKERLLRGM RNWDYQQPYN QVGDFTRWLN IEKGFISDQL LTELPRLEAE DIKLYFPQLL
RQVHIETLVH GNLYKEDALR LTNMVETTLK ARALPQAQWP VFRSLVFPPG ANFVYHKTLK
DPANVNHCIE YLLYVGDKAD RALRAKCLML DQITHEPAFD QLRTKEQLGY VVFSGARTTS
TTIGYRFIVQ SERTPEYLEG RIDSFLANYL TTLKNMSDSE FEGHQRSLIT KRMEKLKNLD
QESSRLWTHV ASDYFDFDLS YEDAAHVKAL TKKEMIEFYE HYISPSSPSR AKLAVHLRAQ
GTSKKSSTGN IADDVKGLKL TSEDKTAQET PVEGNGTKPW AIDDVRAFKS KLGVTPGPQP
VRDLSEFEET DSKL
//
