ID A0A1B8EPZ4_9PEZI Unreviewed; 2594 AA.
AC A0A1B8EPZ4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
DE Flags: Fragment;
GN ORFNames=VF21_07711 {ECO:0000313|EMBL:OBT73382.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT73382.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT73382.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT73382.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV458864; OBT73382.1; -; Genomic_DNA.
DR STRING; 1622149.A0A1B8EPZ4; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096}.
FT DOMAIN 1233..1426
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 111..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2594
FT /evidence="ECO:0000313|EMBL:OBT73382.1"
SQ SEQUENCE 2594 AA; 288933 MW; 6CDC9E9AC0E377E3 CRC64;
MATNGDLNLV ASLVDRLATR LPHRTGSSFR DLRSDDLVSL TRATLIEVSS TYLSTVAESL
VLLLEELTAQ YKDLDTHPPH VVNSELYIIH ILADCFSAHW DAVNRVPNYQ TKNADRHSIP
RSGRGDSHSG TDEEELTQES ATRRLVLPKS LDDILAGRVL EAVKIFLAPY PEQYTLPAST
ILEYSNCRLA QNIPSRLDNS DPEFNSFGKG PGLYSTDGTL QDIEAHARTI IEFLSASNWD
LFFEHLKTSF RLLQVVFPLQ GNGTQAAPVL DDDRNALATL RIVAFIWVDK RKLSLVLSEL
CSCFFHLRKT FQSTLGLALP ILILRWVEQN PDEFVLMHNS HSKIDGVDRL FDIANGMVDS
NRWKAVLYPF QIFLLFLIPD VFEVATSMPS TGRYLENGSM PKASSGIFKK VSFLESLRKA
LRNKNPAAAY CLISLLRIAR HFSLEGNDSA LLSYALDVQE EVRDALFRKN IVGSEGAIFD
NGLMTAAFVS LTHLNFESCN ENIAPQCLSS NAPNDFKLAF VSACSNLAKL PNAHLYTELF
EKITGLIRDH LKDHSHEPYG APKSSSNIAE MTYRCLDFLN VLPLTLFGGA PSNPVDYEVF
FQENFAILVG CLVDEDPKVR RMAGSVTRKL LKNGSVFLLH KGASKDSGFF PANFWRSTSA
VLLNVLEHAA KLGRRGDSVL SFIHDFVESR VELIRSAKDD LISQAETPQR LASLSKLETY
FLVRLCSADI EICQIVTVCV GLLCEETQMV DAAYDSSKSP STIMRNIEVY QDLSSRDFHF
TGLVAFQKRL RSLLRQMKHP SAAVLSAWEI VFGRWYDLSK RVSTHRQDDT LDERSLVEWR
NCSGFLASLA ALCISKQTSS VIEESGLAGL KWIDRPSQDS YDNTLLDRYM TQSVQLLACS
NARIREAMRE VLSTEISPSL YLPLFKTLES ELETLFDGPI DTANRFSDSR IAFAEQAAAL
LKTIIERLGS PADMGAALSV DIGALTLNFA RFLNSVSEGL HTLRIKIKVC QLCEVVTRKK
ELLNLRHDVR IRNQLLEIMF GWIARPGSPK ADNAAMVDGI HRDDALKLQR DLDRACLKAL
SDLTFRLPLQ PPDGQTDADT SDLKSEMFHT YFNRFLSLLS FEPTDQGKND VASNLSAKED
SLSIRELAII ALSNLLGANI DVGLKHSLGI GYHEDLEIRT AFVTVLCNVL AQGTEFNNLS
DVAVGEKYDE LVEVLVNDMT LTIALCDACP SNEVDELTMS LLNIFDSRGL GFILLEELIK
HEVDNTENEA ELLRRNCVTT KMLSVYARWK GSSYLKSTLQ KVLERLIVTA QDLDLELDPS
RTTSAEELQR NTLQLRVVAK VFIDDICSSA PNIPISFRNI CSIISSSVMT RFPDAKFTAV
GAFIFLRFFC PAIVAPDVEG LISTAPSKEM RRGLLLIAKI IQNLANNVLF GAKESYMFPL
NDFLTQNIYE VTAFLRTISV APHVETTGIE MESFDFGSCV ALHRFFYDHW DHVRQKLVAQ
QRKGSLHSPH EIAQGRLPVT EALRNLISNL GPPPMDISWN RPMISMNSPP SYSRFQHFML
SHAGRSTESA ISTRTVYDGG ESKDGLSMIC IILRNIDAET NDYDLLVYCY LKIASRMWHR
PFGIMIDATC YSGQNEPQDA LFKKLDLLTP TELSKNLSCV YVYNMNSAFR KCFRRILRLS
AKNENSAFHP KNVDYHLIGS LQDLQTHFHL SQLHLPKETI SVVTDTRFVF QPVTRLSKTK
GKIEVMIQVG SQFVQVTTTK KQEIVPGLRL HATVNDIFRL TEVDEAPTSI QTEDDSAFGL
RADSGKIVMY FTSPRKSDVL QAIRGAKIKY SKDLKPSQPF ERLIRPQDIP GTLLNISFTN
LASLDQNLRI AAYNLLCALC QTFKFGVNSS FMASKELSIP PSASHFIVNV SRQLAASEPQ
LTADFMNEFF VGWESFPLQQ RPLSLAYLSP WLSGLRSQVL AVEIDGEKAR ERIASIFRKL
IDVAVPDSTL SITLEQIIWP VICEDEVLTD ILVDEILKSA LTSSNNESRI SRLGSIIASL
QVVTVRGKLI SRLRKALNRT SLRPTRLLPE NSVWDEICIL LRLCLAASFN SGVQAHLYLP
EISHIITMLA NTGPTQIRLV VHGLLVNTVH ILCTCFSTDE SKLVRLKVIL ASLSDPNTGQ
QANLSGVTRE GTTISHAQDP TWQILSSTEA LAVLLSEVSS LAASSVDLSN AWRSRWMSLV
ASTAFQSNPA IQPRAFAVMG CLAREDVDDD LLYQVLVALR KSVNRFADEN DNEMLVSIVT
SLTKMMEKLP TTSRYGLQLF WLAMALVRLV PLNLFSCAAS FLEAVLININ TSGDLKGGRM
VPVLLQGRLA LEDSASQLDE SYGIHFNIDN FHFAVCASLV KGLTDTVTKA TTVKVLSTFL
EIASSSALGG RKFPEDLSCL PYLGLVMSRA LTTEEAKGNL WLAGINGDKS STPEDVLAMI
NLDTIKDKEL LLNTAISLVD FRYLEDSVQN RGLVWMNKVA IIRPTVILHL SCPILSILDE
VLLSSQNSVT LKSAQMLLRT LTTNPKLSDT VDTAQLLEDV LEDIGFGGLW VSSTFHSSTE
RDGHCTVLTD KLIE
//
