ID A0A1B8ERD0_9PEZI Unreviewed; 848 AA.
AC A0A1B8ERD0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Proliferating cell nuclear antigen {ECO:0000256|RuleBase:RU000641};
GN ORFNames=VF21_08256 {ECO:0000313|EMBL:OBT73910.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT73910.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT73910.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT73910.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC and is involved in the control of eukaryotic DNA replication by
CC increasing the polymerase's processibility during elongation of the
CC leading strand. {ECO:0000256|RuleBase:RU000641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000641}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|RuleBase:RU003671}.
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DR EMBL; KV458854; OBT73910.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8ERD0; -.
DR STRING; 1622149.A0A1B8ERD0; -.
DR OrthoDB; 118939at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR GO; GO:0017022; F:myosin binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.10.150.10; DNA Polymerase III, subunit A, domain 2; 2.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR026859; Myosin-bd.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352:SF3; MYOSIN-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR Pfam; PF12632; Vezatin; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
DR PROSITE; PS01251; PCNA_1; 1.
DR PROSITE; PS00293; PCNA_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003671};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|RuleBase:RU000641};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..433
FT /note="Myosin-binding"
FT /evidence="ECO:0000259|Pfam:PF12632"
FT DOMAIN 590..712
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 716..843
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 94127 MW; 8C9467C1A4C7C8B2 CRC64;
MDAVVFEDSP LASYFEGEGD GDKSDTCSSD EKQNELSSTN SSPSFAPRGR PTVPSRFRHK
LISPLRINVP QATAATAIRN TYSEALNSRL GKADNTKFQE RFRYIIVASQ LLNDRQYHGQ
GYGSKSPPRS SEDAPVTSLK TFSPRGAAVT ASVAFGVSWM IRWGSAGQDW ISITLRCIII
AALLVAGAII GQAYLRRKWL HYLREQNITE ATRLVGQTQD LDSAVTAALS LIQEVELVSR
GYRLSLPLPP ITRLEDRSQA RRCLQLRRAL FDSAIDLMRR YHQGYLALQP LTEPLNLEKY
YDIYDITTID MQEALTEYTK DEFEDYESLR VLKILISRFV TLRKLFLCCL LALEADGGKE
DFTRWRTALD EIKGLSDIAS TADSRVRSVF EQEESFPVPT TPKSPLAPGR ERWRGQLRKL
NTLSTGIRSL QAKMHVLREE SDKTLDESED ISQLGPHLMI QYDAIGVDLR SLMKEWEAGK
AALANTIDRN ERRISSMSGL LSPTTSLGGL TSVEEGTPAD ALKALNGESR LSPELSSENE
EVFEAIGLPR PGIGPRSTLT REERIVKMKE DRVKRETARE TAEASTKMLL LEARLEQANL
LKKVVDAIKD LVQDCNFDCN DSGIALQAMD NSHVALVSMM LKAEGFSPYR CDRNIALGVN
LTSLTKVLRA AQNEDILTIK AEDAPDVLNL VFESSDSDRL SEYDLKLMDI DQEHLGIPET
EYSATVSMPS AEFKRICMDL MALSESVSIE ASKDGVKFSC AGDIGNGAVT LRSHTNVDKP
ENNVEIELTD SVALTFSLKY LVNFCKASGL SGTVKLCLSP EVPLLVEYAL AGSSYLRFYL
APKIGDDE
//
