ID A0A1B8ERM3_9PEZI Unreviewed; 1619 AA.
AC A0A1B8ERM3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DUF676 domain-containing protein {ECO:0000259|Pfam:PF05057};
GN ORFNames=VF21_05968 {ECO:0000313|EMBL:OBT73975.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT73975.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT73975.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT73975.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the putative lipase ROG1 family.
CC {ECO:0000256|ARBA:ARBA00007920}.
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DR EMBL; KV458852; OBT73975.1; -; Genomic_DNA.
DR OrthoDB; 2331935at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR48182; PROTEIN SERAC1; 1.
DR PANTHER; PTHR48182:SF2; PROTEIN SERAC1; 1.
DR Pfam; PF05057; DUF676; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 60..186
FT /note="DUF676"
FT /evidence="ECO:0000259|Pfam:PF05057"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1619 AA; 179771 MW; 4FD4CB1DF9D6B71D CRC64;
MDLKSHPTSS SSSTSRSLLS SSRSWLPGGG ENQKAEDTIG PLGLNTLYVP SSGPANADLI
FVHGLGGGSR KTWTKPNDPS TYWPKEWLPN DEDMQDVRIH SFGYDSNWGK KSNLGIHDFA
NALLSSILHC PSIPQDTKAP IVFVGHSMGG LVIKRAYLLA RAKNEFATLV SRIQGILFLA
TPHRGADCAQ LLSKVLNLVG GKRGYVNDLN RDSTALHSIN DEFPDCCQDL LLYSFYETIA
TSFAVTKTVI VGRDLATMGY ANERRAYIHA NHRGICKYDS QNDPSYLTVR NALASVFTIL
RERLTTSKEE FNSERRQLDD LLGVSDAPED DFISADSHRM EGSLEWLIIK DNFQEWIHNA
TSPIYSIAAK PATGKTILSG KVIAYLRKLK KQCSFYFFRY DTKEKANVTS FLLSMAWQMA
NSDERILTTC LNILDKDKNL RSDYRTIWRK LFLEGIFKIP CEDVHYWVVD ALDESNNEGE
IISLLMKTAE VSFIHILITS RNRFEPRQSL GEFKVRVISE VILEEDSKSD ITMYLRANMD
ALPSVDRDGQ QSIVRQILEK SRGCFLWVSI VVQELRNVHT STDKQRILDE VPTDMNELYA
RILDIMSKAT YGKELAKAIL TWTVCSIRPL KVPGLHEALQ LDLKVSIDGL ENSIRSCCGQ
LVYIDTNGHV QITHLTARQF LLDAGTDSEF SIDEKEGHRR LLLTGLQFLN SDPIKGSRNR
RSNVSTIARE DSAFINYASN SLCEHISHTS STDRDVLLAL AAFFRSRSVL HWIEYIAKHS
DQQRLVEAGK ALGTFLQEIP AQSSSTSAEV ALLSSWATDL VRLVMQFGKN LDQYPGSIYH
LIPPFCPSET ALRKQFGSSA RSITVRGLRA ETWDDCLATV IDMLEKYSSI ACSKTQFSVG
CFSGKIFIFK QTTCQKIATL QHGEPVRILI FGEVKNVLVS AGSKSICVWD LSSNTKLHMF
EAPQQCMALS LDDEDRLLLG ALKDHCLNYW DLEAGGPPEA VEWTRGLEAM TIQVYRRPTT
AAFGIDCGLL AVIYKGQDIL LWNLDTDSFE ALYSRESGKI AESLGRPYGS SGVRCLVFGN
ASNANLLACA YTDGELVLFD TSIGEVKERI VAFAHVLACS PDGRMLATAD PAGTIQLFNL
ETLQLIYRIG SIEPGLQDLT FSLDGLRLLD VRGSRCRVWD LADLVTAATE EGSGRAADDA
NTTGGITLDP SENSILITSI ACDDIGESFF VGKEDGTVHA YAIDSGLHAG ELFHHAHGVS
IYFLRFEAES QTLISVDSSS RTMIHKLIRR GHSLSATQVL FDYRTHVAVR QVVCQPGLQR
ILISSAQSDM LWSISPDDNN IVASADYEDR EPCRWTNHPH NRDQLIVITH LKAHIYDWKT
LQRLTGETGI ELQGKILPEL SIQSVTPCFN GTALATMFSK PNQPHSKSKL IVWNALDFTP
ESTSAAPDPS YRTLSNTVEV LIGNTCAISG QSQRLIFLGV GQWVCAVDME TAKTNSFVRH
FFFPADWLTT RKDLDLTMNV TKNGDILLIK DDEVAVVRRG LLTPEFVEGG GNTGISAPST
GISALTRRHE DHELNFRGRH GSRGYLRAHA HNGSGLMRVC TAAQEDDLAV SLDVKPDEG
//
