ID A0A1B8EVP2_9PEZI Unreviewed; 1098 AA.
AC A0A1B8EVP2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 03-MAY-2023, entry version 23.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=VF21_05695 {ECO:0000313|EMBL:OBT75426.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT75426.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT75426.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT75426.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation.
CC {ECO:0000256|ARBA:ARBA00024889}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000256|ARBA:ARBA00011375}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the CLASP family.
CC {ECO:0000256|ARBA:ARBA00009549}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV458829; OBT75426.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8EVP2; -.
DR STRING; 1622149.A0A1B8EVP2; -.
DR OrthoDB; 1369289at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096}.
FT DOMAIN 4..222
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 283..524
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 225..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 118214 MW; 21C2932368D0CE7F CRC64;
MGEKLTDVAA QALLTLLRSD SSVDSKVASL TTAKSSIKQH NLPDACVPPL FESARLAMVS
QHTALVNAGF TTLNHLLTRM TRQEPRAIVR ETKATLPLVL ERVGDAREKY RALAGLCLTA
FWRVAGPEVE RGVREGVLGG RSGRAKEGGM GWIVQMHEEY GLQFRSFVPS LMDLLEDADG
MVRDCARNTV IELFQNAPNA AKSDLKKQLK AFNVRTTIVT AITSQLSPTG ADPDPIDQHT
ASPNLRSHHS ESTISASSTT ARPVTPVIEQ RVLEHVEPAY VNTVRELEDT LRDMHPFFDG
KESEHNWLKR EQSCSKLRKL NAGNAPADFH DAWLAGVKAL LDGILKSVNS LRTSLSKEGC
AVVQEIARTA GPGLDPMVEI LLQNLIKLCG GTKKIASQAG DATVDIIISH VSYNQRILQH
VWLACQDKNV QPRTYAAGWL KTLLKKLANH KSTIEHAGGL DIVEKCVKKG LTDPNPGVRE
KMRGTFWPFA QMWPAKSEAV MAILEPAQLK LLQNDPGNPN SPKKTNPVAR PGLAMSKSTG
PPKPSLREAL LAQKKAAMAA KTLPARPGSA MSSFSPMRTA SASSNSSTAT APPGRSRPES
TMSSHGGLSV APMRPTKFRP KEPPRPATAG PYSVRQAPAG ATATPSTTRP AARTPSAATV
SPKRSAVPRP NTSHSSHASQ SSNASPIREK VSVAREASSR EETVVRESPR VAREEAVMAR
ESPRPKQQMQ QQTRDYMSSP SKADEDFTMV IPTLTSLPSS APPPASPPAP AQQRETPRLV
TPAKAVKVYE DPFSSAGDDE TTPRPPLPTT VLEEVSVNEE TFSLAPPPSP PKASSMMNGL
LASPERAKKD VRLLDSGISK VRAQSLDVHG FRKLQSLIRD SDRNIWFPPT AGTESRFDAL
LSGLFTYLAG PATALAPEKV QDVKAQILAT IRAMLRKDRE AFAERGEEGI AALLAARARY
EGRAHIVAGL EVLAQELVGL GDADKVAKTV VRRLEGEDMG VEGCRTLSMG LRMLTGLLEG
PGGYVPGEER AAEMGKLAGR CLESANSGVR MDGVGMCVAL HRGVGEGRFW EVLGGVGGDG
KSLITYYIVK RQREAGGV
//