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Database: UniProt
Entry: A0A1B8EWW7_9PEZI
LinkDB: A0A1B8EWW7_9PEZI
Original site: A0A1B8EWW7_9PEZI 
ID   A0A1B8EWW7_9PEZI        Unreviewed;       998 AA.
AC   A0A1B8EWW7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=VF21_04385 {ECO:0000313|EMBL:OBT75836.1};
OS   Pseudogymnoascus sp. 05NY08.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT75836.1, ECO:0000313|Proteomes:UP000092096};
RN   [1] {ECO:0000313|EMBL:OBT75836.1, ECO:0000313|Proteomes:UP000092096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05NY08 {ECO:0000313|EMBL:OBT75836.1,
RC   ECO:0000313|Proteomes:UP000092096};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus
RT   causing white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX   PubMed=29295979;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen
RT   causing white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; KV458823; OBT75836.1; -; Genomic_DNA.
DR   EnsemblFungi; OBT75836; OBT75836; VF21_04385.
DR   OrthoDB; 179316at2759; -.
DR   Proteomes; UP000092096; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000092096};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    998       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5008607020.
FT   DOMAIN      399    576       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   998 AA;  109308 MW;  88CD84B8F17E7575 CRC64;
     MKIATLLTAA CVAFQGTAAA AVSGKPSTFI RDYDKRDLLQ DVVSLPFKPV TWDEHSLFIH
     GKRAMIFSGE VHPWRLPVPS LWLDLFEKIK ALGYNTVSFY VDWNLLEGKQ GEFRADGVFA
     YEPFFEAATK AGIWLIARPG PYINAEVAAG GLPGWLQRLK GMIRTNADDY MEATELYVAS
     IGAIIAKAQI TNGGPVILYQ PENEYSGGIP PAVFPDAPYF QRVIDQVRKA GIVVPLINND
     AWSGGHNAPG TGLGEVDIYG HDNYPIGFDC SDPTVWPADG LRTDQYSTRV EISPNTPYTI
     PEFQGGAFSP WGGWPIDRCA ELVNQEAERV LYKNNYAAGI SIMNLYMTYG GLNWGNLGHY
     GGFSTYDYGA AIKADRTITR EKYSEAKLQA QFLKASPDYL TAVPTNLSTT LYTDNANLAV
     TPVISSEAPS SFYIVRHNIY NSTETTTYSL NIVTSAGKLT VPRLGGKLTL NGRDSKVHVT
     DYNVGGTTLL YSTAEVFTWK KFDSGKVLIL YGGPEELHEA SIVSTAKPTI VEGKGVTTKS
     IDGNVVLQWK TSASRRIIKV GDLSVYILDR NSAYNYWVPD LADGSAVIVK AGYLVRTAAT
     KGNTLQLTGD FNATTPFEVI GAPKSAKKLT INGQPVAIET SKSTGSWHGL VKYQRPYINI
     PDLERLQWKS TDALPEIQTS YDDSAWPSAD KKTSTNTYRN LTTPTSLYSS DYGFHYGYLI
     YRGHFVATGQ ETTITIYTQG RNAYGTSAWL NGVDLGSNAG NATIGDTNST YSLGKLSKGK
     KYVLTMLMDN MGYDGNWVIG SDSMKNPNGI LHYEFAGRKQ SDITWKLTGN LGGEDYVDKT
     RGPLNEGGLF PERQGWHQQK PPTNGWKASK PTAGISKAGV AFYTAELDLH IPKGWDVPLS
     FTFKKTKSNE KFRAQLYVNG YQFGKYINNI GPQVDFSVPQ GILNYQGSNT VALTLWAQQP
     SGAKLEGLSL TAGTPVLTAL ENIELVPMPK YAKRAGAY
//
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