ID A0A1B8EXK1_9PEZI Unreviewed; 2039 AA.
AC A0A1B8EXK1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 31.
DE SubName: Full=Type I Iterative Polyketide synthase (PKS) {ECO:0000313|EMBL:OBT76080.1};
GN ORFNames=VF21_04869 {ECO:0000313|EMBL:OBT76080.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT76080.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT76080.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT76080.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV458820; OBT76080.1; -; Genomic_DNA.
DR STRING; 1622149.A0A1B8EXK1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775:SF45; CONIDIAL PIGMENT POLYKETIDE SYNTHASE ALB1; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 302..733
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1575..1652
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1677..1754
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2039 AA; 223494 MW; C34898CBF45C0657 CRC64;
MASTQGTHVK EAPAEGQPIS RDEEGPYFGE GSRLYPSATD SYCLGLCAGG FAAAAVSTSQ
TFAELIPAGV EAVLTAFRTA LCTLAVSNDI EEPNNGHHQS WSAVVNIQED EASVLIKRFV
LEKGHPHSSK PYLSAITPSN VTISGSPSIL KEFFAAYSLK FYHIPVELSY HAPHLFHPRD
VDEIICRFDD KLRGSYKPRI PIWSAASGKP IIAENFKALL HKVVTDTLRE PVQWKNILES
TAKLLAYRDF QECAIHALSS NAPSLLSSAI SRGTKMLVTV NDLSAKTGSV PHPRRHSGRL
DQSKIAVVGY SGRFPDSASN EEFWELLRAG KDVHRLVPED RFDWEAHYDP TGKTKNTSRV
KYGCFIKEPG LFDARFFNIS PREAENTDPA QRLAITTTYE ALEMAGMVPN RTPSTQQDRI
GVFYGVTSDD WREVNSGQDV DTYFIPGGNR AFVPGRISYF FRFSGPSLSI DTACSSSFAA
IQIACSNLWR GECDTAIAGG TNVLTNPDNF AGLDRGHFLT TIGNCNAFDD KASGYCRADA
VGSVILKRLE DAQADNDPIF GVIVGAYTNH CGQTDSITRP HEGDQTSVFK RIIRHANVNP
LDISYVEMHG TGTQAGDATE MNSVLSVFVP ERKRMPDYPL YLGSAKANIG HAESASGVSS
LIKVLMMMKH NEIPPHCGIK TRINHKYPLD LKERNVNIAA TSVPWHRTGS GKRSVFLNNF
SAAGGNTAVL LEDAPLLSHS NNISSDPRSS HPVAVSGKSA KSLNDSIKAL INFLELNPDT
PLPALSYTTT ARRMHYSYRT ICSGSDIKSV LDALKKNAAE SDSKALSSTT SVSKIAFAFS
GQGSLYSGIG RQLFESHPGF KADILRFDSI AQQQGFPSFL PLVDGTASDV EGVETVAAHL
ALSCVQMALC RLWISWGVRP NLTIGHSLGE YAALQASGVL TPSDVIYLVG TRAQLLSNHC
HRGTHAMLSI KASSNDIKVY LVGSTCEIAC INQPTNNVIS GPSEEINRLM LLFQSKGLEC
IKLDIPFAFH SAQVNPILEG FESAARGIRY CVPSLPYISP LLELVVSDGV TLDASYLARA
CRSAVNFQGA LRSAKEASLV DGQTIWIEIG SHPACSGMIK GTIGPESITI PSLRKGVDTW
EVLTRSLETL YLNRINIEWN EWHRDFKSSH TVLQLPRYSW DLKNYWIQYR NNFCLTKGEG
TTVIDEPPVE KRLNYAYLSP AVQRVLEEHH AADVSNILVE SDVQDPRLAP VFQGHKVNGT
PLCPSSLYAD IAMTIANYMM KAINMQGGEI GLDVGDMKVD KPLIALQAGN PQLFRVSGLA
NWALKTISLV FYSVNDQGGK KADHATCHVK LTSNQTWLQD WKRNAYLIKS RIASLQKCVD
EGESNKLKRG LVYKLFGAIV EYDPQYQGMQ EVILDSNELE ATAKVTFQVG DGGYGFSPHW
IDSLGHIAGF IMNGNDNVES KNQVFINHGW DAMRCATTFA HGKTYQTYNK MQLVDGTLYA
GDTYILEEGN IAAIFEGVKF LGISRKVLDQ VLPSKPGVIK NAVVPSRPVP NTSSISAAKP
SSKLPIAPDA NLIKLPSNDI ISQIMAIISD EARLDPSELK SNTEFADFGI DSLLSLTILG
RLRDEVGLDL PSTLFSNYPT VEKLQNFIGV DRSPSLSSGS SSQDDTDVLT AELVSEPDTD
RLVDIIRNTI SEETGVPIEE LTVSARLSEL GIDSLLALTT MGKLSEALDI EVPQSLFVED
NTLYDLERAL DMTIKRTHVK ICPNAAKLQT IQEVNNVDSA PHATSVLLQG NSKTATKKLF
LFPDGSGSAT SYSSLTRIFP DIAVYGLNCP WMKTPQDMTV TLEQLTAKYL LEIRRRQPRG
PYYLGGWSAG GICAYEAAQQ LSLAGESTAR LILIDSPNPV GLENPPQRMY DFFDSLGIFG
EGGKPRPSWL RPHFDAFIRL LDEYKVKSFG GKLETHIVYA RDGICKLPTD PRPEIFPDDP
REMLWLLNNR TDFSGGGWCE LVGKENMRIT VLDNVNHFTM VEAGPEIGKL GVFIRKAME
//