ID A0A1B8F054_9PEZI Unreviewed; 1227 AA.
AC A0A1B8F054;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=gluconokinase {ECO:0000256|ARBA:ARBA00012054};
DE EC=2.7.1.12 {ECO:0000256|ARBA:ARBA00012054};
DE AltName: Full=Gluconate kinase {ECO:0000256|ARBA:ARBA00029835};
GN ORFNames=VF21_04125 {ECO:0000313|EMBL:OBT76966.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT76966.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT76966.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT76966.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC EC=2.7.1.12; Evidence={ECO:0000256|ARBA:ARBA00001329};
CC -!- PATHWAY: Carbohydrate acid metabolism. {ECO:0000256|ARBA:ARBA00004761}.
CC -!- SIMILARITY: Belongs to the gluconokinase GntK/GntV family.
CC {ECO:0000256|ARBA:ARBA00008420}.
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DR EMBL; KV458810; OBT76966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8F054; -.
DR STRING; 1622149.A0A1B8F054; -.
DR OrthoDB; 2230730at2759; -.
DR UniPathway; UPA00792; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046316; F:gluconokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02021; GntK; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR006001; Therm_gnt_kin.
DR NCBIfam; TIGR01313; therm_gnt_kin; 1.
DR PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF01202; SKI; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 567..645
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1227 AA; 135720 MW; E8EFEA54D0149DDA CRC64;
MAADIAHSST IQHISSQSFL SPVDTSLVSF RRQRTFATNH VPHTIDELMR LRAFQQPEEP
ILAYPIHNTD YLEYTYRELD VFAYRVGQQY VQHTTQRRSS AEKEKVVALL GPSNLDYLIS
VLALTKSGFT VMFLSTRLSD AAYLSLLEST QCRDLIIHES FSTTAERLRK TMPDLCAHPI
AQSASYAFPN QENDQDTCLD CHLDLELEAQ KICWIIHSSG STGLPKPILQ THSAALTNYE
NNLNMRGFIT LPLFHAHGIS SVFRAFTSMK KIYMYNANLP LTHNTLLSIM AEHRFEILYG
VPYALKLLGD TEEGVKALVK LQVVMFGGSA CPDSLGDRLV DAGVNLISHY GTTETGQLMT
SFRDRSDKVW NYLRPSANLI PFLRWESRGM DLFELVVLDG WPSKVATNRS NGSYATKDLF
TPHPSIPNAW KYSARLDDTI GLLNGEKVGP TDMEQAIRDN KYVREAVVFG NGKPQLGMMI
IPSEETVGMP ESQIIEYIWP VVESSNAAAP GYARISAEML KLLPASATYP QTDKGTVIRQ
AFYKLFEKEI EDVYSRSEMA PSTNAPSSEL EIRAFLKEKI CNLNSQAELD DDTDLFSIGL
DSLQALQLRS LILKKLPVSG KALAMNFVFD FPSANALTRE LVLLQDGQTS KSIPVQEQMA
QLIEKYGSFQ HHIPKPNSNE GQYIVLTGAT GSLGAHIVAQ IAPLPDVKQV YCFVRAKSER
DATMRVISSM NTRGCYHQLS LEARRKIVAL PSDFSKEDLG LSSAVYAEIS LNITCLIHCA
WSVNFNLSLQ SFEKDCIAGA KHLMGLCLSA GRPSPASFNF CSSVSAVAST PPGEAVAEDV
PPSLDDAQNM GYAQSKLVTE NIVHRAACQT GMKSRTLRVG QIVADTQHGI WNATEAIPLM
LQAGQTIGAI PALDESPLWL PVDVVAKAVF EISLSDSPAG TTNVVATQSF HWTRDLLPKL
HATSLSFEEV GQREWISRLR ASNPDPVQNP PIKLLDFFAK KYDNDNIVRK GLQYNTLRAQ
NLSPALATAE ILSQELVDKF VGHFIATSWN TTEKMQGTII VVAGPCGVGK STVGTEIARK
LNCSFIEGDQ YHDAQALAKM ASGQALDDED RWLWLARLRA EAELEISTNG KGVVVLACSA
LKGRYRDVLR GVGKRIRTVF VMLQVEEKVE LARRLEMRTG HYMKADMVES QMAILEGPRV
DEMDVLPVDA KNMPQDLAEE AVGVLGL
//
