ID A0A1B8F0K1_9PEZI Unreviewed; 1070 AA.
AC A0A1B8F0K1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
GN Name=TIF32 {ECO:0000256|HAMAP-Rule:MF_03000};
GN ORFNames=VF21_05081 {ECO:0000313|EMBL:OBT77129.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT77129.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT77129.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT77129.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000256|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; KV458808; OBT77129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8F0K1; -.
DR STRING; 1622149.A0A1B8F0K1; -.
DR OrthoDB; 10990at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.860; -; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A; 1.
DR PANTHER; PTHR14005; EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03000};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000};
KW Initiation factor {ECO:0000256|HAMAP-Rule:MF_03000};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03000};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_03000}.
FT DOMAIN 340..524
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 808..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 96..123
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT COILED 624..671
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT COMPBIAS 808..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 120920 MW; 26C3AD7DF71C309D CRC64;
MPPPPHQKPE NVLKRAGELM GVGQSPAALV LLHEHITSKR SRNVPIASLE PVMLLLVEQS
VEQKKGKLAK DALYQYKNIS QNTNVGTIEL VLKKFIELAE NKVQEAQAKA DEIQSTLETT
QATASVDDLE ASETPESILL STVSGEQSRD RTDRAIVTPW LKFLWETYRT VLDILRNNAR
LEIMYQSTAM QAFAFCQKYA RKTEFRRLCE LLRNHVQTAA KYSAQQMHAI NLNDPDTLQR
HLETRFQQLN VAVELELWQE AFRSVEDIHT LLNLSKRPPK NIMMANYYEK LTRIFLVGEN
YLFHAAAWSR YYNLLRQSAA IVASGQGKKS ENPAASEADL TKAASFVLLS ALAIPVISTS
RSRGALIDVD QAKNNKNSRL THLLGMSAAP TRAVLFKDAM SKGLLSRARP EIRALYNILE
VDFHPLSICQ KISPILAKIG ADEEMAKYIA PLQQVILTRL FQQLSQVYET VDVNFVENLA
RFPAPFDVSR DTIEKFIMNG NKKGDLAIRL DHATGVLSFD TDVFSSAKAV HTGSAAGSAE
TESQSVQRLQ STPSEIVRTQ LTRLAKSLYV TCQYVDPSYN QARVKARDIA LAKAKAGAEQ
EHHETLARKE IIHKRKEAAN EIIARKEKED ATKKKIRAAQ LQEAEDKRLA QEQKEREEKR
MKAELDRVRK DELKKQIADL KIGTKALDID LEDLDNLDGN RLRAMKLAQL EREKNDTSEK
LRIAGKRIDH IERAFRKEEA KKLPADYEEQ RKRDLEAYDK TKSQVLRDAE AKHAEDLELS
KRLTRITPIY EEFKTDVVAR RHDEFEKRRR DAEKELEKQI NQRRKEHRER KIREKREREE
QERILREEEE RAAVELAEKS AREERRRQEF AELKAQRDKE RQEGLEKAAL QARREEEALA
RRAGARATGG LPVRAAEPER SASSDRRPPL PLAGAKLGWR EKEALRAAGQ EVPSERTASP
AAPAAPAPFA RTDSNDRPSG PPRLALAGAK PSWRDKEAAR AASGTSPAPE SRDREAPVIA
RTASGTGPVR GRTDRNENER ESRSPAPPAE PLRASGGAGK YIPKHLRDKA
//
