ID A0A1B8F0Q7_9PEZI Unreviewed; 2498 AA.
AC A0A1B8F0Q7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Peptidase A2 domain-containing protein {ECO:0000259|PROSITE:PS50175};
GN ORFNames=VF21_05060 {ECO:0000313|EMBL:OBT77107.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT77107.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT77107.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT77107.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the putative lipase ROG1 family.
CC {ECO:0000256|ARBA:ARBA00007920}.
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DR EMBL; KV458808; OBT77107.1; -; Genomic_DNA.
DR STRING; 1622149.A0A1B8F0Q7; -.
DR OrthoDB; 179786at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 12.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 12.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF05057; DUF676; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 46.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 22.
DR PROSITE; PS50088; ANK_REPEAT; 22.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096}.
FT REPEAT 933..965
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 966..998
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 999..1031
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1059..1091
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1076..1091
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT REPEAT 1092..1124
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1125..1157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1158..1180
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1195..1227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1228..1261
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1262..1297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1298..1330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1433..1465
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1535..1557
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1603..1635
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1848..1881
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2018..2050
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2232..2264
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2298..2321
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2330..2352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2365..2397
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2398..2430
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2431..2463
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2498 AA; 276028 MW; B491678CA0B3C5F1 CRC64;
MATPVTPTRP GSLSTLITGD TSPNSSPATS ISDVLSTSRP PDSPSTTTSF ASRTSHRTKF
SRGLGKFKDI PKSVFGKKNL SSPSIQEESI PIHEKNGIWE LTDPCEDEDG FMDVVAVHGL
QGDWKYTWED DSKNWLRDFL PTQVQQLRIL SFGYDSSIAF SSSTPDLRDL ATKLLNTLGR
KRDTSQEKKR PILFICHSLG GIILKQAMII ANERASLHAW FLEHIKGVVF MGTPHLGSEH
ANWASFFANL LEVTIGPTTN TALLASLKIK APALIEICHQ FPERASKLKI LSFYELGICN
GLRHRIVERE SAILGRENER MAGVDADHMA MCKFARKESQ KYQEVFGLVR NLIRDIREDD
VSPRDSIHFD RKDSREILAS LFDTHVSNRA SAGTRVEGTC QWILTNPEFS LWNLSNDDSP
VDTALSLLWI TGAPGTGKSI LTTFVVDQLR NRFPGASISS FSFDNGKRPI ETLLRSVLHN
LLSSNPKLLP HAAKEWQVKG KSFSTDWETL CEIWSQCCLD LNGADTIWVI DALDECEEYG
RIRFLQQLAK VVRTLQSVGN TSRFKVFFTS RLEKDIQDAL SGIRPLRINL DDEVGNLTLD
ITKVIDKGIK DLTDEGVIPL DKADLLKQRL FAESDKTFLW VTLILGLLRT SELLPESLES
IIRDLPAGLD STYRQLLAQV PEKQQPSTKV VLQLIMAANK PLNVREMNLL LKVQGGHSRE
QDLRPLFETL SRQIQHQIQH LYGSFIRIID TGDGDKHVHF VHKSASEFLL AENLNKSESQ
GELTSKPLWY AMDPIAAHAE IAKRCIWVLK LIGTSSKSLE KWQGHGDFDF DVFVRNFLED
HDMYEYAAVN WASHLHMSEA TMTDDILFHA LRLYRNSGIY TTWSQIFWAL QLLPQPHNYS
AFHMTAYNGH AKLLDKLLDD DDDETTKDSK SEGGDAIIHI AADRGHPKVI RVLKNYGADF
TIRDKVGLTA LHRAVKANHL KTVAALIEAG SSVDSRKQDG STALHLAASE GNCEMIELLV
EKGSTVQATN QQRKTAADLA FNKGHGEAHR RLQNYQVDHG VTDLDQAIIE GNLSEVQSLV
DSGADLTLMD ERGSLPLHHA ARENHLHIVK FLLERNVGRD IEDENGLTAL HLAARRGRTK
IVELLLKYGA KIDAKSKDGS TSLHEAASGG SEEVVQLLLQ QKESEIQRVN RTNDEGKTAL
NCAAAFGFHL IAQSLISRGA STETRDRDGR SPLHQASSNG HIEVLLELFK SSKVDVNCID
LKGATPLTLA ARGTSPSHGQ VVKLLLEKGA DPKWAERDKS TPIFLAAESG NILSMEYLLK
KGVNPDERNT LRYTPLGIAA AKDHEEAVLL LLDNDAKDVS QNSLKRPPLS WSSEHGHLRA
VKRLLKFEAV DVDISGNDER RTPLSYAAAN GHLAVVRCLI QEANPTIDFT DHEDRTPLSW
AAGGGHVGVA SLLLENGADQ CARDLEGRAP ISWAAINGSF QLLKAMIDRE GHLPESTITN
NGKTLLALAC ENGHESIVRF LLSRSKGKLN RASKEGFSPL HLAASNGHDK IVDYILSLDG
IDVHLPSKMG YTAFSLAVQG GHFQVAQNLI RFDPSVLDTE TIEQKSPLII AVEGGHSDMV
SFLLSKGVDP NFQNQDQETP IFLAALRGDL VTVNVLLSDS RVRFDLERTN KAGVTPLLAA
ACYGHLPVVK SLTKHAIEHD LKAMIKQKDQ HSFSPLSAAV FNGHPGVVDF LFKCEEYDPM
EHRNNKGSLL ILSLNSKNKE VIKMILSRRF ELDVPDKSKG RTPLLWAAYL GDEDTIQFLL
SECTIVRNAT DFKDSTAIYL AARNGHELAL KLLLENGISD INAPESEMGS TPLIVAAKNG
HSNIVALLLQ QEGIQVNQQD NHGCTAFLWA VREGHEFLVR KLSEDSRVEC RVHDSKRRSA
LSWASEKGYS RIVQMLINLD LREINDVDTY GSNPLWFAAS CGWIYILENL LMQGSSSTVA
SGPHRRTPLM QACNEGHFSV VERLCEEKDP GIHLKDVYGY TALSLAAKGG HEQIVIYLLN
NGADPNTQAT KSKRTPLMEA AMVGSLKVFR ALTDWPTTDI NLKNDADRTA LWFAINYRNT
GYDEMVYILL RKNVQTNVTD LDDVTYLMLA ARNITSVPTN EPILQKLLDL GKIDPGAMEL
PAGSTALMKA TIEGCDVTVK QLLQHPTAHV NADQGDFDNM TPLAIAAING YSTIVRMLLD
CRVTVDSYTL IKRETPLMFA ADNGKSLVVD QLIAAGANVN ATDKTGATAL FGAATFGCCR
TIRQLLANGA IPEVRSKTGL TALHLAAKKG RTTSVRLLLE KIPVTVRDHQ GRTPMSYAAE
AGQDSVVRYL LSLFEGSEFE VRDSQHKTPL TWATIGGNVE LVSLLLNRGA KKDILDRNGR
SLVSHAAEKG HLAVMHYLIS EGSNVDTQDN AGRAALSWAA GEGHLSVVRC LLDNGADPNQ
RDKKGQLPQI YAANNEKKQV VELLRRYSSI TAKRKSSV
//
