ID A0A1B8F284_9PEZI Unreviewed; 1762 AA.
AC A0A1B8F284;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VF21_03756 {ECO:0000313|EMBL:OBT77656.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT77656.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT77656.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT77656.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV458802; OBT77656.1; -; Genomic_DNA.
DR STRING; 1622149.A0A1B8F284; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092096}.
FT DOMAIN 951..1143
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1179..1350
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1417..1728
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1762 AA; 195457 MW; F5F5809A649C1B64 CRC64;
MSFRQNGQHR YGHVPPQQYG GQQPAQNAGL GLQRQSSFDN GDDAQFFDNT NGTRPPPAQP
SAYAQQNHYG SQRSHGGGQD ELYLDGSGRG HRSPERPPYS PQPSQYTNQM YAGQGGGVPQ
TPSTPSAYNP QHFPRTQSQS QAHAQTPNYN PQLYSSQSVS SQHHPYVPAA YQTQQPPVPP
RPPAQSPYMQ QGPSYGTSPM PQQSQTFNSP PLVQNQHASP YWSPQIPQSQ QYGAAPQVPN
RVPTRPAYEP SYEPSYQPSY NPSLPAPLPP KPAQYSAPPS APSYSANGTT YGSTNDYRAQ
SNPSPYPAVT QMPMGPSYSA AYDDFGSDAY GGRPSRPSSN SNPPQPVPVE NDVQHISQLR
RHPTGRALPT APAIEDTDPF DDDQDRLSTE ARAQELMFQE IEAAIGANTV SRPQISQPHA
PMSGDLLDNE FGDHPNGLGS EARTPTAGQN PDQMYEFEDS DEAEAASGVL ALKLAEEEEA
NHNNRGSMGS FGLYSQQRPQ ETSQDASSDS DNYAVGMDLT MLGGGLNIPM SYGNDIAARD
EMQDESRPLP DMRGRESYAA APASVLGGLT YHHIPSDDIH HPFPPTHDPG AEPPIQQQHR
RSFDEGDERS SLGSRLTAES RLSGRSGSDS PSREEFPDIP YHPGISAASA HNRPLPAVPS
LSENRTPQLL PAGSYRNPPN QQQDPQRPSQ MYPPDGPESY ATQDLLNPGG QFVPRSASLT
SHSSTPLVVP PMRSRTDAEE RQARQRALRG HAVDGFDAGT PQSTVPLDLP ALPPGRRKKA
TPENLRSSDY KKCREPWALS GIADWIREMY CGESGDGEAD LRVKSIQDLL VALFTHKVPT
MNTADAEVIS AVVVNDMLQA SVLVEDEEWV KFGPGEISGV LWQMSGSGCY SPKVHEHEIH
GRCYSHHCHR TLKKINLHAQ KMAPAKRAEP WHEFFKLTKV QIDSADSKEV LRQNNLHEII
MSEDKFMVQL DVLRTIYRDE LQAWQPPIIG QAKLPRFIQQ VFGRAEAVKN VNMNHLLAQL
KYRQQEEGPW VTGFSSIFRE WTRRAGQVYL DYAASYPNAT YLVRREMEKN VLFRQFLDQA
QSNKVSDRLG WDTYLFAPLK RLQQYTLLLK EVLKHTYVDS EEKTNLMIAI AEVDKVTHDC
DDKVNEENKK IEMQELQTKL FMRPGFRRVD LHLDHLGRQL ILQGDLQRPG SSRFNWLETR
AILFDHYLVL AKAVVQRDSS GLKNKEVFDI SKQPIPMQLL VLESTNDEAV VKSKGLGSVT
TVTRSAPSTS DSRITRASTA SDRPALDHAS TSTSLSSMSK VSSNTTAEGD ARSMFPFRVK
HLGSQEVHTL YAPSAQNRQE WCEKIMWAKE RHAASLFSQN AEPFRLKVLA DTAFLIDPTQ
ASGRSSAGIP VAGTPLDRAI KDIEREYGHA RQSPVCRAQV NCATAFAMYG KSMVAIGTDN
GIYISEVNNP RGWIRSVQST RITQIAVLED FSICLVLSDK SLIAYHLDSI VPVSNFPAPQ
HDSARRAPQK ISGSREVSFF ATAKMKDRTL VFYKGRGNIA TSSSSTFKVL EPVFQKSSEK
RSKLFGRSKS GGGTTEFFRE FDEFYIPVEC YGINLFQSYI SVCTHKGFEL LTLDKKITMS
IPDPNQPNIA SIAERLKDMR PLGMFRLSDA EFLLCYQDCG VYIDKHGEVS RSVVLEFVGK
AKSAAMYGAY LILFDTDFVE VRNAENGRLR QIIAGKDVRC LDYGVQGAST MAKRSLKVAM
AHPEMANCQL VVELVLNDGQ RE
//
