ID A0A1B8F2B5_9PEZI Unreviewed; 1266 AA.
AC A0A1B8F2B5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OBT77647.1};
GN ORFNames=VF21_03737 {ECO:0000313|EMBL:OBT77647.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT77647.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT77647.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT77647.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV458802; OBT77647.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8F2B5; -.
DR STRING; 1622149.A0A1B8F2B5; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092096}.
FT DOMAIN 535..730
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 913..1207
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 143074 MW; 16414F520868D616 CRC64;
MANYQGPRPN GGRQSDYGQP PSSNNQRDAA FSNIFGAAPP PGRSQTMTSS NQSPNMMPPP
GRTQTMGSQY DGRSPMGREP PPRMPPPRQP PPRQPGGYPP QSPSYAPNGQ AGPNGYYQGP
QRPASNSGPQ VRDQQLPPPP PRLDQRRPYP GPQRVDMRQQ PNISQQQQFA QQQRQPPQRA
YSGPAPAMNS DPYRSQSMAS ISRPQMYQAP PSNFQQAPAN AFRHAPYQNN QQMSSKITAQ
GRPVPERTHD ERTMSMTSYP QGRDHQTMSG RVIPNRRAEE PQERTNGYQI ETPGAAGSVT
RTTSMASTQV TEGSGRSMSM ASTVVPPESV NNRTSVKSNG SGTGRRAATK APLVYPALLS
RVGECFRDRI QTGDRTKNDL AYKHAFSGAE AVDVISYIIK TTDRNLALLL GRALDAQKFF
HDVTYDHRLR DAPTEMYQFR ETMMDDPSDT PEVNGVFVLL TECYSPTCTP DHLCYSIACP
RRLEQQSRLN LKPQPGLRRE DSQANLHDNE PDEQKLWINT VSKEIADSVG DREKKRQEVI
SEIMYTERDF VKDLEYLRDF WIFPLRGLVR DVPPPIPESR RERIVRTIFS NIVDPPSIHG
VSSKFAESLT ERQRKHPVVS AVGDIFLEFV PQFEPFITYG SNQLNAKFEF EKERSLNPFF
SKFVDETERR KESRKLELNG YLTKPTTRLA RYPLLLDNVL KYTDPASQDI TDIPKAIKLI
RDLLTRVNAE SGKAENRFNL RQLHEQLRFR PNERVDLKLT DEGRELIYKG ALKKSPTDPS
EIQAYLFDHA MLLVRVKMVG KKEEVKVYRR PIPLELLAIK EMDDVVPRMG VVKRPTSSLL
PGNKSNTADT TKGFPISFRH LGRKGGYELT LFASTAGSRK KWLEYIDEQQ EKLRARGDFY
NKTTLSAGFF TAMNRVNCAA PFDGGRKLIY GTDTGIYVSD RRSREAGAKP KRVIDVQNVT
QVDVLEEYQL LLVLSAKSLL SFPLSALDPN EPTLGKRSKK IQSHCNFFKT GICLGRHLVC
CVKSSALSTT IKVFEPNDAM SKGKKQKGFK MFNSGQDELK AFKEFYIPTE SSSIHFLKSK
LCVACARGFE VVSLETLETQ SLLDQADTSL DFVARKENVR PIHIERLNGE FLLNYSEFSF
FVNRNGWRAR PDWRIEWEGL PQSFALSYPW ILAFEPNFVE IRNIETQAVH IIPAKNTRML
HTSTREILYA FEDERGEDIV ASIDFWPAGQ RPDARMSIMP PAPSTAPQLP ALQIEGGSSR
HSHVRQ
//
