ID A0A1B8F5X2_9PEZI Unreviewed; 1706 AA.
AC A0A1B8F5X2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=VF21_02369 {ECO:0000313|EMBL:OBT78983.1};
OS Pseudogymnoascus sp. 05NY08.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622149 {ECO:0000313|EMBL:OBT78983.1, ECO:0000313|Proteomes:UP000092096};
RN [1] {ECO:0000313|EMBL:OBT78983.1, ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|EMBL:OBT78983.1,
RC ECO:0000313|Proteomes:UP000092096};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05NY08 {ECO:0000313|Proteomes:UP000092096};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KV458790; OBT78983.1; -; Genomic_DNA.
DR STRING; 1622149.A0A1B8F5X2; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000092096; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000092096};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 370..698
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1369..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1706 AA; 187385 MW; F1FE9753DF605C35 CRC64;
MNISQPVSSA IGSVDFAFLS QDEIKRLSVK AIQNPTTFDT LLNPVPGGLY DPALGAWGDI
QCTTCHLGAL SCPGHVGHIT LPVPVYHPTF MDQLLRLLRA KCAYCHHFKM SRKDVNLYHC
KLRLIQAGLL SAAEELDNID IVAKKAAAVE QEEESSDSGD DNGVESTIKQ RLIFVKKAIR
DAKATPWDWK LEKNESVAEA RREVIKSFLK SITISKTCAN CRAISNGFRK DRFVKIFEKP
MSAKEEAKNA QQNLKAVNAM RVVSKDASKK SNGYASDEGI ADIDLSSNEE DEGVGHTLDV
AGGLVSKERS TSGTTAISKQ KPSTTGTERY VNPMEVRASL TLLFEKEQEI LSLVYASRSS
SKKAAVITSE FFFLQTLLVP PNKYRPEART GAGEIAEAQQ NALYKQILTA GHMTAQISKE
LDNPALADLK YRRRDFSDLQ ESWVKLQDSV NSLIDRDRNP IQGAAGKKNE DGIKQKLEKK
EGLFRKNMMG KRVNFAARSV ISPDPNIETN EIGVPPVFAR KLTYPEPVTS HNFKELQQAV
INGADKWPGA AAIENENGQV INLRTKTPDE RQSLANQLLA SSGVGANGAR NKKVYRHLTN
GDVVLMNRQP TLHKPSIMGH RARVLPGEKT IRMHYANCNT YNADFDGDEM NMHFPQNEVA
RAEALQIADT DHQYLAATAG KPLRGLIQDH ISVSVWMTNR DTFFDRATYQ QLVYNCLRPE
SGHIIGERIE TVPPAIIKPF PQWTGKQIIT TILKNITPLG YTSLNLISKS QVPADRWGPK
SEEGQVLFQD GELITGILDK SQLGPSGGGL IHSLHEAHGP TVAGKMLSIL GRLLTKFLHI
RAFSCGMEDL LLTSEGEKIR REKLKDVHLI GLEVAAKYVT LEDRKPTAND PELRNRLEDV
LRDDTKQEGL DVMMNGSSNK LSSEITKACL PHGLVKQFPK NQMQNMTVSG AKGSAVNANL
ISCNLGQQVL EGRRVPVMVS GKSLPCFKPF ETNVRAGGYI ANRFLTGIRP QEYYFHAMAG
REGLIDTAVK TSRSGYLQRC LIKGMEGLKV EYDTSVRDSD GSMVQFLYGE DGLDVTKTKH
LTDFKFLLQN IESVVAQMKL GDDLEVIGEH QEKIQKMMKR GIKTAKANTI DVSDPVLAHY
HPGRHLYSTS ESFNRSLNSY IKENPDGLIK SKSNPNAYSK KELGPILNVK YLKSVVEPGE
AVGIVAGQSI GEPSTQMTLN TFHLAGHSAK NVTLGIPRLR EIVMTASNNI STPSMTLQVN
EEMTEEAGQK FAKGISKLSL AEVLDEASVS ERIGKGTSQS RAKIYDINLK FFPPQEYRDT
YAIDVADVIS TLEKKFVPKL QSLARKALGK KKGEKKLKSA ANTAAVPEIG KSVGVIEEAR
PEGEKAPRDE DDDDEDDDGD ATNAKQKANR GQAVSYGAND DEDDAVQTQM EREASPEDED
DGDDEGFQGG SRGSRLGNDE DYENDEEDTG AADQALSDDR QSRVMSKNAD VSRFRCDEGG
SWCKVTLEYD ASSPKVLMLN ILESALHASL IQQISGLDTC TYVAGKGSDA AVVYASGVNL
KAMQMYSDYI NPNKISTNDI AAMLEHYGVE ACRATIIQEL SGVFGGHGIA VDNRHLNLIA
DFMTRGGGFS PFNRNGLKGS VSPFLKMSFE TTIGFLKDAV MDGDWDDLRS PSARIVIGRT
SKVGTGAFDV LTKVPVDSDT DHVMSG
//