ID A0A1B8FEN6_9PEZI Unreviewed; 848 AA.
AC A0A1B8FEN6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=VE02_09562 {ECO:0000313|EMBL:OBT82052.1};
OS Pseudogymnoascus sp. 03VT05.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622148 {ECO:0000313|EMBL:OBT82052.1};
RN [1] {ECO:0000313|EMBL:OBT82052.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=03VT05 {ECO:0000313|EMBL:OBT82052.1};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
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DR EMBL; KV459611; OBT82052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8FEN6; -.
DR Proteomes; UP000091872; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 196..299
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 681..770
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 848 AA; 96190 MW; 15FCBD149C48B83C CRC64;
MALFSSEALS TGWEFKLSEE SQPESWLPVA KVPTVVHLDL LDNKKILDPS LDMNELQAHW
VGEKSWTYRC KFTAGSKTEG AKTVLVFEGL DTFATVRLND TEVLKSENMF IPYHVDVTAT
IASNGLNTIE IDFESALLRA REIGKEHPEH RFIGHQTEPE RIAVRKTQCH WGWDWGPKLM
TAGPWRPVRL ETYVSKIENL WLESTLDADL NACRGNISAH VDGEAGAKVL FTLSSEGTSV
FEAECTPDSK GAIQTPFVLQ KPSLWYPHGY GAQARYVLEA SLVIDAVVLH RVQQKIGFRR
VELIQEKDGN GKSFYFRING IDVFAGGSCW IPADNFTPRI SSDRYREWLT LMVEGNQIMT
RIWGGGIFEE EVFYDVCDEL GILVWQDFLF ACGSYPTYPS LLESIEAEAR SNVRRLRHHP
SVVIYAGGNE DYQIQQTYNL DYDYDGDKDP ESWLKSSFPS RYIFEHLLPK TLAEEDPEAI
YHPSSPWGDG KHTTDPTVGD IHQWDVWNGL MKPYQDFPIM GGRFNSEFGM EGYPHMSTIM
AFISDENEMH AQSLTMDFHN KANFHERRLA TYVHENFRVS SADFKYWVYL TQLLQSEAMH
YAYTRWRREW GTPGDRRCGG ALVWQLNDCW LTISWAVVDY FLVKKPAFYA IQRALKPVSI
AVARTHNEWT KGHVAPDLTS KYDVWIASSN VAGVTVAKVK LRFISIKTGL DVVDPQTEDV
EIQPNGTTTV RESVTIDNSP TLEAFVLSAT LSIDGEVIAR DADWPQPFKY LSFKEDRGLT
ITLSESRDTI SIAAQKPVKG LVFAERMGLS FSENGLDILP GNEYSVHVGG LKEDEELEWM
FLGDGESQ
//
