ID A0A1B8FM69_9PEZI Unreviewed; 624 AA.
AC A0A1B8FM69;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE02_05446 {ECO:0000313|EMBL:OBT84623.1};
OS Pseudogymnoascus sp. 03VT05.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1622148 {ECO:0000313|EMBL:OBT84623.1};
RN [1] {ECO:0000313|EMBL:OBT84623.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=03VT05 {ECO:0000313|EMBL:OBT84623.1};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; KV459470; OBT84623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8FM69; -.
DR Proteomes; UP000091872; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF115; DEHYDROGENASE XPTC-RELATED; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..624
FT /note="Glucose-methanol-choline oxidoreductase N-terminal
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008607821"
FT DOMAIN 45..354
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 477..615
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 560
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 603
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT BINDING 122
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 624 AA; 66713 MW; 6840097573DB865C CRC64;
MAWLKAPLLG LTPLLALSGV VNAYPGTLGA LRDREANAEQ LAASYDYVIV GGGQSGLVIA
NRLSEDPSKS VLVVEYGYFD NDPAQLDPSS AANYRPINMF NVSSVPQPGL GGRVSGAFAA
SVVGGGSTVN GMMFDRGAAD DYDNWEKLGN PGWGFSGLLP YFKKSTNFTA PRADLAEEYG
ITWDAKKAYG TNGPIQATFP DWLWPTIKVQ WKAWAELGVP IQKEAAAGDA YGAFWVPTNN
DQTYRRSYAR SGYYDPVASR KNLKIITGYR ANEVLFSTKK HAESVTIQER GTPNGAPTIS
VKAKQEIVLC AGWLHTPQVL QRSGLGPKDL LDEAGIKQIV DLPGVGANLQ DHAVTSIGYS
YATDLSPNPS SLYTNATFAA WAAEQWLDRK GPLSVGVGNS LSVPSLPQMS ANYKSIIAKA
QVQNAAKLLP STYTSVNVKG FVAQRDLLLK TFSKRNNGVV EITFSGGGTS SLSNEKPLSR
GTVRLNTTDH YAEPIVDFNT LINPTDTDIM VESLKFARKW FATDAMKQLS PSETSPGGNI
TSDADLAAYV VRSMGSTTAH SSGSAAMAPR HLAGVVSPEL LVYGVTGLSI GDISLIPMIP
STHTCATMYA VAEKAADLIK KRCK
//
