ID A0A1B8G770_9PEZI Unreviewed; 587 AA.
AC A0A1B8G770;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Peptidase S53 domain-containing protein {ECO:0000259|PROSITE:PS51695};
GN ORFNames=VE01_10336 {ECO:0000313|EMBL:OBT91678.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT91678.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT91678.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT91678.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC ProRule:PRU01032};
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01032}.
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DR EMBL; KV460283; OBT91678.1; -; Genomic_DNA.
DR RefSeq; XP_018125411.1; XM_018279739.1.
DR AlphaFoldDB; A0A1B8G770; -.
DR STRING; 342668.A0A1B8G770; -.
DR GeneID; 28843722; -.
DR OrthoDB; 1405251at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04056; Peptidases_S53; 1.
DR CDD; cd11377; Pro-peptidase_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015366; S53_propep.
DR InterPro; IPR030400; Sedolisin_dom.
DR PANTHER; PTHR14218:SF42; PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14218; PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2; 1.
DR Pfam; PF09286; Pro-kuma_activ; 1.
DR SMART; SM00944; Pro-kuma_activ; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51695; SEDOLISIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU01032};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01032}; Reference proteome {ECO:0000313|Proteomes:UP000091956}.
FT DOMAIN 184..586
FT /note="Peptidase S53"
FT /evidence="ECO:0000259|PROSITE:PS51695"
FT BINDING 545
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01032"
FT BINDING 546
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01032"
FT BINDING 564
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01032"
FT BINDING 566
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01032"
SQ SEQUENCE 587 AA; 63849 MW; EC57866F0232BA6D CRC64;
MHGLEDGLNG ARETGYCRDT VADGWTKTSH ASADTPLNLR IGLKQLNLEQ AEELVNAVSH
PRSETYGQYW APQQILEMFA PSSDAVSDTI VWLLEAGVPR SSIALSAGKN WIKVDTTVGV
AESLLDTTYG VYESSEEDFE LVACEAYSVP ADVRRHIDLV TPTIQFDTRG TTIRQRVKKR
DVLSPNPRKL PGWHKNHKAE SLDNCREKEE SVEGNSYGIV EYAPQSYNHE DLNGFFSVYD
NVPNDTAPIL ERFDGGYLSK ETGSGTRGKS NLDLCGGVVW NLATNNNFLD AIDGSYCTFE
GGDITWDATY PHDASSPDAY TGEPKCGTQN ATHVISVSYG RNEDARPASY TARKCTEYMK
LTLMGATIMF SSGDTGVTGI SGRYLNEDGS YTPRSPNYGR FAPCEFPSIT SIVTLRSPVN
GTIHDREIVA TRSSPGGGFS NIFALPSYQA ETVASYYGHH DPGYNFSQYN NMQQVHGYPD
VSLNAQSYIT GIVGGFQAFT GTSASSPTFG AMITLINGAR IAAGTGPVGF INPVLYEHRE
EIFNDVVEGH TSGCGTDGFT AVEGWDPASG LGTPDFVRLK KVLMRLP
//
