ID A0A1B8GAJ6_9PEZI Unreviewed; 1126 AA.
AC A0A1B8GAJ6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=CAMK protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE01_09076 {ECO:0000313|EMBL:OBT92850.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT92850.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT92850.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT92850.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. CHEK2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005575}.
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DR EMBL; KV460261; OBT92850.1; -; Genomic_DNA.
DR RefSeq; XP_018126583.1; XM_018278492.1.
DR AlphaFoldDB; A0A1B8GAJ6; -.
DR STRING; 342668.A0A1B8GAJ6; -.
DR GeneID; 28842462; -.
DR OrthoDB; 2045964at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR44167; OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED; 1.
DR PANTHER; PTHR44167:SF18; SERINE_THREONINE-PROTEIN KINASE RAD53; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000091956}.
FT DOMAIN 109..165
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 279..563
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 756..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 308
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1126 AA; 125018 MW; DD687B8395FE3A47 CRC64;
MDDDATQPAT QLVMDPRRLG DHVSDLEDDD LTDIFCILHP VSLSALNAVT HIGDVAPEHT
VSRASAPIKI RGGPDITDPN TMDLAEQGLV SRDIALRLSA KLIDPLAGYT FGRNTQRCDF
VLRYPTVEGT SRISNVHFRI FITIDGIVMI EDQSTNGTVV EGKKLRFKDK ENDAPHKHTL
SHGSLVSLSM NAPDEDLRFV VRIPQREGIY EDIFSQNLAD YFARMSLLRK NRDAQVKTDV
AGQAPDIFAV QNYPGGNGHG PDQTLINRRP KEWRGGVKYN KSRVIGKGAF ATVYMISAKY
DGTVYAAKEL EKRRFVKNGI LDQKVDQEMR IMSSIKHPNI VQYIEHVDWE DHLYIIMDYV
PEGDLGSLVS SRGTLSEVST KTLAKQMFSA LKYLHDKGIT HRDIKPDNIL VQSFDPFHVK
LTDFGLSKRI ENEDTFMRTF CGTLLYCAPE VYSEYLSYFL DPADIQAQAR IKSKKFKRYD
QAVDLWSLAG VLFYCLSGSP PYPAKSGTTY QQLLHSIMRG PLDIRPLQLA GVSEEGIDMI
KSMLHNQAPY RPSIEELEES QWINPGSTRQ ADVRLEHTAS QLSIQDQSDS LGTSDEIDLI
NAMVDTKNLE IPSSFISGDE GSSGNSEKFA VNNTTSNQPR LFGEVNLSAL RSSGVIPQER
LNLPLSDTGD NNTAQSSFVN VDAAPLDFES QNNSYQSSIL PGQHGNMPPS HLGTGTAPSL
LGAESMVGNL AMNSPSPTTV IDVASPQETF TGAVPDFRES MKSLRRQRDP NGDDEPLAKR
AKSSRAIDIE LSKTVFWDAR DRSTHHLDYP VMRNSEYQEA KALAKMYGEE FKHGESVFET
VVGAYRRSAS ATPEPPTRAQ SEPVAAGGPA KLNRDERGFS EDRAVLPTGS WINGVPSPEI
SQYLPGHSKA AKAASKPEEK PVISNDVFQP PHRILAKLVG TSDSVLPNLT LNITSLFTSW
GRGFDNKLRH ADRTDNRIPK YALKLALWQP GTKPSASPPT DKDNAYAFYI ATKASHGIKV
NGIVLPSHDC RSPQKSPAKY WGKLQHGDVV DVWTQDSNSE VVLRFRFDCF WGESKEPRRS
GQFFSAMKEG PLKDELESFC QWEESAFFQA KYDAEVKAKG IKEGGK
//
