ID A0A1B8GBQ7_9PEZI Unreviewed; 1495 AA.
AC A0A1B8GBQ7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=UDP-glucose:glycoprotein glucosyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE01_08422 {ECO:0000313|EMBL:OBT93279.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT93279.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT93279.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT93279.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family.
CC {ECO:0000256|ARBA:ARBA00006351}.
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DR EMBL; KV460255; OBT93279.1; -; Genomic_DNA.
DR RefSeq; XP_018127012.1; XM_018277847.1.
DR STRING; 342668.A0A1B8GBQ7; -.
DR GeneID; 28841808; -.
DR OrthoDB; 1734at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0003980; F:UDP-glucose:glycoprotein glucosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd06432; GT8_HUGT1_C_like; 1.
DR InterPro; IPR040497; Glyco_transf_24.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR009448; UDP-g_GGtrans.
DR InterPro; IPR040693; UGGT_TRXL_1.
DR InterPro; IPR040694; UGGT_TRXL_2.
DR InterPro; IPR040692; UGGT_TRXL_3.
DR InterPro; IPR040525; UGGT_TRXL_4.
DR PANTHER; PTHR11226; UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR11226:SF0; UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF18404; Glyco_transf_24; 1.
DR Pfam; PF18400; Thioredoxin_12; 1.
DR Pfam; PF18401; Thioredoxin_13; 1.
DR Pfam; PF18402; Thioredoxin_14; 1.
DR Pfam; PF18403; Thioredoxin_15; 1.
DR Pfam; PF06427; UDP-g_GGTase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1495
FT /note="UDP-glucose:glycoprotein glucosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008608518"
FT DOMAIN 42..221
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18400"
FT DOMAIN 269..400
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18401"
FT DOMAIN 406..647
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18402"
FT DOMAIN 660..862
FT /note="UDP-glucose:glycoprotein glucosyltransferase
FT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18403"
FT DOMAIN 1181..1446
FT /note="Glucosyltransferase 24 catalytic"
FT /evidence="ECO:0000259|Pfam:PF18404"
FT REGION 1456..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1495 AA; 166584 MW; 7E9185EEA59080C9 CRC64;
MVQLGNIWSL TGSALAFSCL QSIKVSASPT INVALAASFT SAPYLIELLE TAGDENSTSY
FPLLDRIAEG HFKDARTDLE LYNSFVKVLR DDGHLDSEGL ASYSLALSLR TSAPRIEAQY
QFYDTAIEPS GDDSSCLAWV LFGGKKHCSP ALDEAHGTYN GRRGTEQLQF DRITGNLSAP
ASILYADITS PEFSQFHKKL IQKAQKQEIS YRIRHKKPTA QEPRPLIIGG YGVELALKRT
DYIVIDDREA EAQVQVGSAK AEVVLEDEEL ADLKPLSASE LVSLGLKASS FIMQNENPFE
VLTRLSQDFP RYSSAIAAHN VSSDFAEEHL YNRGQLVPAG TNVVWINGLQ VPARHMDAFS
MLDILRKERK HLKKFSQLGL TGSQTISLLS HKDIAFTKAD GEPARFDWRD SDGDVIIWLN
NIEKDKRYDG WMTTVRTLLQ AGYPGQLPQV RKDLFNLVFP VDLSNLEDVE LVVTQLSEFV
KRALPLRFGL VPLTNSNAAL EQAKIAYYLL DSYGLSTMVA YLNGYFASKG TPSSRNANFE
AAIEERKLLG DKVAKSLEEV LDADEANGSI EHSKQWSARL GANDKVPPVF VNGAAVPRDE
TWMQGMSQRV QMDLRLMQQA VFENTVTDDH WPPMLYLHDA ASGRNPFLMP ENDKDLQLFD
VNAIYSDYAE ALEGLPVMKS DPSTVQDDWA YMILIADVES AQGKRLLMAA AEFIKKNPSV
ELVIVPSSES PAGILSVHEY MAKRSFQPLK SVDDLDSLVE AVSITAGDEE RQITTQISEK
WSAIEGLVGS LGLKPGQQGL LLNGRLVGPI PNEVELGVNE LDQLLSFERT KRIKPVLAAV
KALGFSDAIS DPLASSKLTS LVTLSFISNV PEGIFEQAST LRIDSFKAWK SEFTAIEIGD
ESTASIHIQV ALDPASQESQ RSIPILKVLS ELDGVYLKLF LNPKDILKEI PIKRFYRYVL
ESKPMFNADG SLKDIKAQFV SVPQEALLTV GMDVPAPWLV APKQSVTDLD NIKLSSVNGD
VNAVYELQHI LIEGHSSEKE TGQAPRGAQL LLGTAADAHF ADTIIMANLG YFQFKANPGF
YKINLQEGPS SKIYSIDTLG ASGRDAAQPD ETTEISLISF QGLTLFPQLS RNPGQETEDV
LEPTTDLKDD IVSKGRKLAQ NILNFGSKKS TTAVQTTQAE INIFSVASGH LYERMLNIMM
VSVMKHTNHT VKFWFIEQFL SPSFKQSIPS LAAAYGFDYE MVTYKWPHWL RAQSEKQREI
WGYKILFLDV LFPLSLDKVI FVDADQIVRT DMRELVDIDL QGAPYGFTPM CDSRTEMEGF
RFWKQGYWKS FLRGLPYHIS ALYVVDLRRF REIAAGDRLR QQYHQLSADP GSLANLDQDL
PNHMQAHLPI FSLPQEWLWC ETWCSDESLA GAKTIDLCNN PLTKEPKLER ARRQVPEWGV
YDEEIAGVFR AAKNGGEQEV GAKNQKSRTL EEEEGRNEKS RTMEAETTKG VKDEL
//
