ID A0A1B8GCN9_9PEZI Unreviewed; 683 AA.
AC A0A1B8GCN9;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 03-MAY-2023, entry version 24.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=VE01_08326 {ECO:0000313|EMBL:OBT93609.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT93609.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT93609.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT93609.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV460252; OBT93609.1; -; Genomic_DNA.
DR RefSeq; XP_018127342.1; XM_018277751.1.
DR AlphaFoldDB; A0A1B8GCN9; -.
DR STRING; 342668.A0A1B8GCN9; -.
DR GeneID; 28841712; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 219..413
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 512..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 73027 MW; 29BAF22C9800D6B0 CRC64;
MASTTTTTAP PPQFAFRTLK EIGLTDAAPL YAAVPGFTRP QGNSRCCIYS PCGRYFAWAA
VEGVHVVDSA TGLPVADLPV PNVYELAFSP RGSYVITWER PSKDEAGDAV KNLKVWRTIE
EGERTVLGRW VQKSQTGWNL QYTADEKYCA RVVTNEVQFY ESHELAVPWN RLRAEGVADF
ALSPGNNNSV AVFIPQRKGQ PAAVKVFNVP QFGTAVSQKT FFKGDKVQLK WNALGTTLIV
LAQTETDKTG KSYYGETTLY VLSANGGFDS RITLDKEGPI HDVTWSPNSR EFGVVYGYMP
AKTTIFNTRA VATHSFPLGP RNTILFSPTG RFVLVAGFGN LAGQVDVYDL SKDYRKLTTI
ESGNPSVCEW SPDERFLLTA TTSPRLRVDN GIRIFHVSGS IVYNEDMVEL YHVAWRPSLP
GPNTVSNPLA PVPQHSSAAQ YLTTVKTPSK PAGAYRPPGA RGTSTPLHFK REDEGGAAHT
VSNGTSLVSA PVFGHQGPRA RRAVPGAELV EATPAASAED ENLSKAALKN KKKREAKKAK
EAEIKAGGGA PAVPPGFEGV AAGGQGQRAN GNANGNANGG RGAGRNTPAA ASAAPSTPAR
NRAPAPAAAV PVPEPVVVVE EVLSPGGGSA HAKKLRGLQK KMRAIEELEM RLAGGERLED
TQMRKIGTKA SVVKELEGLE VGV
//
