ID A0A1B8GHG1_9PEZI Unreviewed; 1211 AA.
AC A0A1B8GHG1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=MSH6 {ECO:0000313|EMBL:OBT95271.1};
GN ORFNames=VE01_07661 {ECO:0000313|EMBL:OBT95271.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT95271.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT95271.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT95271.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KV460237; OBT95271.1; -; Genomic_DNA.
DR RefSeq; XP_018129004.1; XM_018277094.1.
DR AlphaFoldDB; A0A1B8GHG1; -.
DR STRING; 342668.A0A1B8GHG1; -.
DR GeneID; 28841047; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956}.
FT DOMAIN 1047..1063
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..185
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 134388 MW; 5219CB9E6B80A27C CRC64;
MAKSEKSTTT PSRPAPARKQ ASSAAPSTSK NQRSILGFFS KAPTAGLPLL KKQASPPATL
EGAQTDGPAA ARTPAGKAVG KVGKAVKKMD RTPVASSDVI EPPSSQGGGD KNAVVQSSPS
RRAKRPVSYE EPDEDDEDDE APVAARRSKS RKKVIDSDDD DDEDVFVGEV DEESDDDDMD
DFIASEDSDA APSKSKKRKR PSPSKTPSRK RSYAPSPLPP VVDDDVEMGD SQGSSAQRWK
YDPDDTKPLQ PRSSNIIRKP KPTSSDLAKK QKPSKSEPEH RYTWLANLLD MDRNPPGHPD
YDPRTVYIPP NAWTGFSAFE KQYWQIKQKF WNTIVFFKKG KFYELYENDA TIGHQLFDLK
LTDRVNMRMV GVPESSLDHW ANQFVAKGYK IARVDQMESA LGKEMRERED SVGGAKAKKV
DKIIHRELAC VLTKGTLVEG SMLEDDMATY CVAIKETTTT ADDLPTFGIA FVDTATGQFF
LSEFVDDVDL TKFETFVAQT RPQELLLEKS CISVKALRIL KNNTSPTTIW NYLKTGKEFW
GADVTKRELD CSGYFLTEEP GADEEWPATL TEAKDKEIIM SAFGALVQYL RSLKLDRDLL
SQRNFAWYSP IQKSTTLVLD GQTLINLEIF ANTYDGGQAG TLFKMLNRCI TPFGKRMFRQ
WVCHPLADAK KINERLDAVD MLNADSTLRE QFTGQMTRMP DLERLISRIH AGVCRPDDFV
RVLEGFEQIE YTMSMLGAFG GGDGIIDRLI SGMPDLIGPL EYWKTAFDRT KARDERLLVP
ERGIEEDFDD SEDRILGIKQ ELFGLKKEWA AKLGTKGVQF KDIGKEIYQL EVPVKNSKAV
PKDWTMVSST KSEKRYYFPE LKTLVRALQE AQETHGQIVK ATAGRFFQRF DKDYTTWLTA
VNIIAQLDCL ISLARASAGL SSPSCRPSFV DTERTVVDFT ELRHPCVLPN VTDFIPNSIR
LGGSEPNINL LTGANAAGKS TILRMTCIAA IMAQIGCYVP AESATLTPID RIMSRLGAND
NIFAAQSTFF VELSETKKIL AEATPRSLVI LDELGRGTSS YDGVAVAQAV LHHVATHVGA
IGFFATHYHS LAAEFAGHPE IAPRRMAIDV DEAERRVTFL YRLEEGVAQG SFGMHCASMC
GIPRKVVERA EVAAKEWEHT SRLTVGLEVA KRGTYVPLGW QSDIAWMLKE GKLGEGADRG
VEVLMKAIAG I
//
