ID A0A1B8GHM3_9PEZI Unreviewed; 1164 AA.
AC A0A1B8GHM3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VE01_06609 {ECO:0000313|EMBL:OBT95340.2};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT95340.2, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT95340.2, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT95340.2,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; KV460236; OBT95340.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8GHM3; -.
DR STRING; 342668.A0A1B8GHM3; -.
DR OrthoDB; 1945480at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR47470; CHOLESTEROL OXIDASE; 1.
DR PANTHER; PTHR47470:SF1; FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000091956}.
FT DOMAIN 150..410
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 605..669
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 126900 MW; 7C16CF5931D5FEFE CRC64;
MVFSITKQEP NPASHQGKMS NTNGTNGSNG AHRVNGANGA NGKHEIPPVS KPHRVDFART
TSRGPPIDTT WERVNSFPLP PHTATPGGPT ARSQAKVRSY GQNEDPKCFP RISKPVELLR
TSYDVLVIGS GYGGGVAACR MARAGQTVCL LEQGKERWPG EYPSTLLEAT KELHISGEVP
SVISKPKMID KGDPTGLYHL IMGEGQNAFV GNGLGGTSLL NANVFLRTDD GTMGLHNWPP
ELRKPGALND YYELAEKMLE PQKYPDEWPE LPKLNMLETQ ANHLGWGDKF RRVPQTTRFS
AGANSTGVEM NASALTGQDT TGLNDGSKSS TLVNYLSDAW NWGAEMFCEC EVRYIKEHPD
EGYIVYFAWH GSGRGAFTEH LHEDLMWVHA KKCVFLGAGS LGTTEILLRS KAMGLSTSST
LGTGMSGNGD ILAFGYNCNE NVNAIGREFP SPYHPIGPTI AGIIDCREGH ENPLDGFVIE
EGAIPKALAP LFQVMLELMP GTAHHDVSLI GNVRSKLASI GSHILGPYYQ KGSVEKTMVY
LVMSHDSNQA ILSLKNDKPL LKFLGVGRSD HVEYLNDILA QATSAVGGTF VNSPFYAALG
KQEITVHPIG GACMSSCGTG RTGTTNHFGQ VFKGNGKETH EGLIVTDGAI VPTALGVNPL
ATITALAERS VKYTADRMGV TIDYDTKNGL LDLFGFPKHV ITGDDSIVNA ESLIEETAAG
KVSGFEFSEV MSGFIHFGEN MEGDRTDDFE VAARTGRGLC EGARFFLSVK AWNTHTIVRR
PDHSAMLTGT LVCAGLPGSP FMIKRGDFGL FSANQSISGT KNLTYSFQMI GTDREKYQFE
GFKTVNAGVV LNPIALWRAT STLYVTIKRL NGTVIGRGIL HIKPTDFLSE ARTLTPTGDG
LIAKATSTIS FLSYFAKQAA SLFFTPFSPL QYPSHTPRGF INTCTSDGAI AVIASDGVKT
YMNKWESTHP DPAYPVHDLF MVPGASVDHQ IFSLQTIPKN AVQYFTERGY RVWVLTHRIG
MNMQPTDKWT TFDARLDIRA ALAYIRSVCG NRKIYTIAHC MGSVALASGM LDGTIPVEWI
KGLSCSQVFM NPQWARINMA KVMMPFDLTR AYRLLGGNWF SCSSSEDDTL VQRAIDQVLR
FYPVEPREMC NNVACHRTSF VFGR
//
