ID A0A1B8GHU5_9PEZI Unreviewed; 643 AA.
AC A0A1B8GHU5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=K(+)/H(+) antiporter {ECO:0000313|EMBL:OBT95423.2};
GN Name=KHA1 {ECO:0000313|EMBL:OBT95423.2};
GN ORFNames=VE01_05155 {ECO:0000313|EMBL:OBT95423.2};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT95423.2, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT95423.2, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT95423.2,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
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DR EMBL; KV460235; OBT95423.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8GHU5; -.
DR STRING; 342668.A0A1B8GHU5; -.
DR OrthoDB; 6504at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..418
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 477..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..564
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 71105 MW; FA6A8E2E39DF1440 CRC64;
MSNTISSAVS NTAAAAAAAT TALRATPQGG ILEGANPATY DPKNPIILFI IQVTIIIIFC
RLLHYPLSLI RQPRVIAEVI GGIVLGPSVM MHIPGFKAAI FPDASLPILN LVANLGLILF
LFLVALETDL QMFMRNWRVA LSVGLAGMIL PFGLGCGIAY GLYHQFRTDE GIVPISFPVY
MLFIGTALSI TAFPVLCRIL TELNLLGTPV GVTVLAAGVG NDVVGWVLLA LCVALVNNGS
GITALYVVLC TIGWILFLFY AVRPCLIWLL RRTGSIKNGP TQGMITLILL LTLFSAWFTG
VIGVHPIFGG FLVGLICPHD QGFKVKLTEK IEDLVTVLFL PLYFALSGLN TNLGLLNDGT
AWAYVVGIIA VALVGKIVGG TLAARSCKLV WRESLTIGVL MSCKGLVELI VLVSSPSSRP
HQQLLTSVEH RSPSQDPLYK NLHHVRHHGP RHNRHHFPRN QRPLSALVPE EARSLEARRH
RLGGQRAPRL RRLPRETRVH TNPQTPRLPT PRVSSSAIHT HRPSRRRKAR PHHPRAQIAP
PLRPRRPLLR NYHPRTRARS PRRAPPPPHR AYLVRNESFS SRRLLVRSYP QHLPHLCAPQ
RTPRLWYNQH RPCHLLRHRA ALQNLFSLSR PPSRPLAILP PGR
//
