ID A0A1B8GIG6_9PEZI Unreviewed; 1661 AA.
AC A0A1B8GIG6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Dicer-like protein 1 {ECO:0000256|ARBA:ARBA00020797};
GN Name=DCL1 {ECO:0000313|EMBL:OBT95631.1};
GN ORFNames=VE01_05942 {ECO:0000313|EMBL:OBT95631.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT95631.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT95631.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT95631.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; KV460234; OBT95631.1; -; Genomic_DNA.
DR RefSeq; XP_018129364.1; XM_018275400.1.
DR STRING; 342668.A0A1B8GIG6; -.
DR GeneID; 28839328; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR CDD; cd18802; SF2_C_dicer; 1.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF62; DICER-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00657}.
FT DOMAIN 208..390
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 531..700
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 733..823
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 1167..1278
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1325..1492
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1523..1595
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1661 AA; 186720 MW; 79FAC3978B17B15A CRC64;
MCHTVGTAAP LHGQSGVDGA PTEGNMDLDI EISQVTTLKS PTTPKPPTTP AHQADSPPSI
VSLPSAFNMQ VPEVMVPALA TRSTDAVIED LRRRGLHPGA PTVDKEPLTV YVEEVSRTQK
EDIAIEDEDA GDESESDDES PAHPSENQEL SYEKSVRESY IRSRVFQAAK DSTAPETKGD
DKQSVKWLIK DSGSQEIISS PREYQIELFE KAKTQNTIAV LDTGSGKTLI AALLLRHVID
EELERRASGG DKRIAFFLVD SVALVFQQYA VLKCNLNHKM EQFCGDMGCD LWSKELWEKH
FNENMVIVCT AEVLFQCLHH SFITIKQINL LIFDEAHHAK RNHAYARIIK DFYASEPDQS
LLPRIFGMTA SPVDARTNIK KGAAELEALL HSQIATASDA SLLQYTNKKT REEVAYYDPL
PPPTESQLFK RAHQLVGGIK ECSKPLEYAV TASSDLGSWV ADRVLLISFT GEDVKRLGAQ
IESNFHKQAQ IDPIPLSNLE DRKEKLRSAQ QIIMEHVFAS PQLSRSQLSS KVLGLASKLR
ERFERTTFDK CIVFVKQRYT AKLLADLFAS PQIGTPHLRV GSLTGTRNRS GADLESSFRN
QVITLRRFRQ GEINCLFATS VAEEGLDIPD CNLVIRFDLY STVIQYIQSR GRARQDNSVY
FHFIERGNKV QDALAREVRR NENILKEFCQ ALPEDRLLSG NNYNMDYFLA KERNIMRTYT
EPSTGAKLTY RMSLSVLANF VASLPHSSES TPHPEYMMTA MGAKYVCEVI LPENSPVHGA
IGRPANTKQV AKCSAAFEAC LSLRKGKHLD EYLLSTFKDR GPAMRNAQLA ITSKANTDYD
MRTKPSMWAA GETPSELFLT ILSLKDPVQL DRPSQPLGLL TRGPLPPLPL FQLYFGGGKH
TAAVSTAVGS LAVSSETLEL INTFTLRIFK DIFSKEYESD PAQMPYFIVP ISDTDTTCRA
RLPVDLISWD ILRIVSDNQW LTWDKSTPES FFEDKYIIDP FDGSRKIWAR KVTHAYKPLD
PVPPNTAARS ARKNNLNILE YSCSLFKVAR SKRTFSETQP VIEGDVIPFR RNFLDDHDDP
ANSGPTKCYV VPEPLTISAL PTLIVAMAYT FPAIIHRIES YLIAVEACSM LHLPISADLA
LECMTKDSRN TDEHGDEQVE FQRGMGNNYE RLEFLGDCFL KMATSISLYT LHPDSNEFDF
HVKRMLMICN KNLMDVALQL KLYEFIRSQA FNRRAWYPEG LVLKKGKAAQ APKKHKLGDK
TIADVSEALI GAALLTPSNG HAMDHAVRAV TELVCSTDHA IEKWEDYFKG YTKPKYQITA
STASQRNLAE QIEITHDYHF HYPRLLRSAF IHPSYPFVYE RIPNYQRLEF LGDSLLDMAC
VNFLFHRFPT KDPQWLTEHK MAMVSNQFLG AVCVALGFHT QLLQFNPIIQ SSITEYVCEI
TEAREQAEQD AIRDGKLPSD CARDYWLHAK LPPKCLPDII EAYIGAIFVD SSFNYEEVER
FFDLHIKWYF EDITLYDTFA NKHPVTFLHK FLQQNMGCAK YRITASSMPD DSSGTPPKIL
ATVMIHSQIL VGVERDSARY AKIAVAQKAL EILKAGTLTQ FRQTYRCDCK EKGLDVEDCN
MEDAAQESME DHVGIKTLDV ESALGADIGV EGSRNGSISS A
//
