ID A0A1B8GM75_9PEZI Unreviewed; 1003 AA.
AC A0A1B8GM75;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:OBT96906.1};
GN Name=MLH3 {ECO:0000313|EMBL:OBT96906.1};
GN ORFNames=VE01_05438 {ECO:0000313|EMBL:OBT96906.1};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT96906.1, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT96906.1, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT96906.1,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KV460225; OBT96906.1; -; Genomic_DNA.
DR RefSeq; XP_018130639.1; XM_018274902.1.
DR AlphaFoldDB; A0A1B8GM75; -.
DR STRING; 342668.A0A1B8GM75; -.
DR GeneID; 28838824; -.
DR OrthoDB; 9570at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000091956}.
FT DOMAIN 718..926
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 408..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 109916 MW; 8A54D0C7D9EBF6C2 CRC64;
MASSPAIAPL PPEVVAQIKS SVSITSVNGV IIQLLKNSLD ASAGKVDVQV DYGRGGCIVE
DDGLGIAPAE FQPSGGLAKL HHTSKYTSDT ETHGTQGCFI ASLAALSLLS ITSHHHLHRS
HNSIALSRSQ VISRHTPAPE AQNLVSLNHG TRVTVRNLFG DMPVRVKQRA IENAESSRNP
KDWDSLRKEV MALILAWQGP ISVTIKELSS NTKLRTLRIS SRQRNINDDG ALISHICSTL
AQASFIPSVD TSSWVSASGS TSTVSIRSGI SLDPAPTKGI QFMSFGIHPL SNEDGRNILF
EEVNRLFANS SFGIVDDLPQ LDETEKKRRA EDKRYKSDGF TNKELKGSGK GVDKWPMFYM
RIDIHGPIPN HDPVEDVFDD EKTLISITKL LQAVIVEFLR SNNFNPKFIR PPGSPSKRKA
ESSEVDMGRI EPSGSSTKAI YDMPGTSVSP KKRAITKLPT RHPSPRPSSP FDIWPRVKSG
RVPTLVKTSK RELSNVDDGV QAAKGAQPSK RPSAGSKDTG RDSTSKIEKS LPRSTTPLIS
KSGTVSQLPF MDVAKPTRRP AMAPKKEVPI NESPPDMEKD ELVPWTDPTT KENCFVNMRT
GSVQQTPKLS VKPTPETRHG LQTLNRKYAP KSHDTPTQPH QPSDWLNSIL TNWNNPVFPP
AEPPIPQIQP DWTDTHTQSI LHGHHHTCTQ AAIDRAFQVS ATSSTGHLSK SGLQQARVIA
QVDRKFILAR MPAAAASMDD GVSGEDMLVI IDQHAADERC RIEALMADFF LPPSPLPGLG
HDELAPRVRV ERLEKSIVFE VADAESELLE RHRRHFADWG VLYYICPGEG MDKVVLTALP
PGIVERCRAD PKIAIELIRR EVWGVDGRGG AGPSRLVRGN ETAEQTDVEG GATPDWVARM
QGCPAGILEM LNSRACRGAV MFNDVLERRE CEMLVRRLGE CKFPFLCAHG RPSMVPLVGV
GEGVVVGMER EGKVREKGVG DRDGGEGFGR AFRMWKSETR RSS
//
