ID A0A1B8GNB9_9PEZI Unreviewed; 328 AA.
AC A0A1B8GNB9;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1 {ECO:0000256|ARBA:ARBA00021935};
GN ORFNames=VE01_04636 {ECO:0000313|EMBL:OBT97296.2};
OS Pseudogymnoascus verrucosus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT97296.2, ECO:0000313|Proteomes:UP000091956};
RN [1] {ECO:0000313|EMBL:OBT97296.2, ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT97296.2,
RC ECO:0000313|Proteomes:UP000091956};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria.
CC {ECO:0000256|ARBA:ARBA00002238}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; KV460223; OBT97296.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8GNB9; -.
DR STRING; 342668.A0A1B8GNB9; -.
DR OrthoDB; 1330359at2759; -.
DR Proteomes; UP000091956; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF777; MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN A; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 26..114
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 123..219
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 228..317
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 328 AA; 36053 MW; 516C9B4FCEA4A0AF CRC64;
MSDPAEKALK PKPSVRLLQM QDFFSQPVTA AFCAGGVAGA VSRTVVSPLE RLKILYQIQG
AGRQEYTQSV TKSLARIWRE EGWKGFMRGN GTNCVRIVPY SAVQFGSYNF YKKFFEPTPG
ADLSSFRRLI CGGAAGITSV FFTYPLDIVR TRLSIQSASF AALSNLHKSK LPGMWSTMVM
MYKTEGGILA LYRGIVPTVA GVAPYVGLNF MTYELVRKHF TPEGDKNPSA LRKLAAGAIS
GAVAQTCTYP FDVLRRRFQI NTMSGMGYQY KGVFDAVKVI IAQEGVKGLY KGIVPNLLKV
APSMASSWLS FEMTRDFLVG MNDDVSNI
//
