ID   A0A1B8GPH5_9PEZI        Unreviewed;      1085 AA.
AC   A0A1B8GPH5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=VE01_05041 {ECO:0000313|EMBL:OBT97727.1};
OS   Pseudogymnoascus verrucosus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT97727.1, ECO:0000313|Proteomes:UP000091956};
RN   [1] {ECO:0000313|EMBL:OBT97727.1, ECO:0000313|Proteomes:UP000091956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT97727.1,
RC   ECO:0000313|Proteomes:UP000091956};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT   white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000091956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT   white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KV460220; OBT97727.1; -; Genomic_DNA.
DR   RefSeq; XP_018131460.1; XM_018274507.1.
DR   AlphaFoldDB; A0A1B8GPH5; -.
DR   STRING; 342668.A0A1B8GPH5; -.
DR   GeneID; 28838427; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000091956; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          24..90
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          386..424
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1085 AA;  118855 MW;  56B51A06F36DCE79 CRC64;
     MDQGRFVELL QSIQIPDTEK VKAATTELRQ TYYPHSESLL WLLQILASHD VQAIRQQAAV
     EALRLVPKHW ATLDGPKPAI RESLLKAALN EQSSLVRHST ARVISAIAGI DLEDGEWADL
     PGFLMEAAKQ PQVGHREVGV YILFTLLEVV GDGFIDKLPI LFQLFSITIR DPESPEVRIN
     TMLALSRIAM LIDPEEDRKS LKSFQDTVPS MVAVLKSTID DNDEDRAMQA FEVFQTLLGC
     ESALLANHFK DLVQFMIELS VEKSITDETR SQALSYLMQC VKYRRMKVQG IQGMGEQLTI
     KAMQIAAEME DDDDDEDEIT PARSALSLLD ILASSLPPRQ VIVPLLTSLP QYANSEDPAL
     RKAGILSLGM VVEGAPDFVA TQLEQIMPFI LQLLNDSDIN VRQAALHGVS RLAEDLAQDM
     SQSHATLVPA LLKNLDAAAS QTDKISTGII IGSCLALDSL VDGMEAEISS LYISELVPRI
     GRLFEHPDFK VKGASAGAMG SIASSAEEAF LPFFEQTMKA LSEYVTMKDS EEELDLRGTV
     CDAMGSMATA VGGVAFQPYV QPLMAASEEA LHLGHPRLRE TSYILWSTMS KLYEKEFAPF
     LDGVVKGLLE CLEQEESDLD VELGEEASDL LGTEVVVAGK KIKVVQPSTD EDSMDDDEDD
     DDDWDDLTAV TAVALEKEIA VEVIGDILSH TKDLYIPHLE KTVEAVMTLV DHSYEGCRKA
     AIGTLWRAYA CLWALMEDHT GKKWTPGIPL KEQPSQELIK LGEVVATATM TVWGDEVDRA
     VVTDINRNIA ATLKLCGPAI LTQGNMLEQV TTILAALVTR QHPCQMDMGD DEDQEDVGET
     SEYDWLAVDT ALDVVIGLSA ALGSQFGELW KVFEKPVMKL ASSQEAFERS TSIGVVAECT
     AHMGAAVTPS TATLLKLLLH RLTDEDPESR SNAAYATGLL IQHSEDVNTY GPAYPEILRK
     LEPLLQTERA RTLDNAAGCV TRMITAHPDK VPIADVLPVL VGLLPLKEDY EENAPIYGCI
     VGLYQAGNST VQELTPQLVP VFAAVLGEPK EQLEEETRAK LIETVKYIAK QQPALIQGHA
     VLAAL
//