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Database: UniProt
Entry: A0A1B8GSN6_9PEZI
LinkDB: A0A1B8GSN6_9PEZI
Original site: A0A1B8GSN6_9PEZI 
ID   A0A1B8GSN6_9PEZI        Unreviewed;      1388 AA.
AC   A0A1B8GSN6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 2.
DT   31-JUL-2019, entry version 16.
DE   SubName: Full=Dicer-like protein 2 {ECO:0000313|EMBL:OBT98854.2};
GN   Name=DCL2 {ECO:0000313|EMBL:OBT98854.2};
GN   ORFNames=VE01_03430 {ECO:0000313|EMBL:OBT98854.2};
OS   Pseudogymnoascus verrucosus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=342668 {ECO:0000313|EMBL:OBT98854.2, ECO:0000313|Proteomes:UP000091956};
RN   [1] {ECO:0000313|EMBL:OBT98854.2, ECO:0000313|Proteomes:UP000091956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 10579 {ECO:0000313|EMBL:OBT98854.2,
RC   ECO:0000313|Proteomes:UP000091956};
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Comparative genomics of Pseudogymnoascus destructans, the fungus
RT   causing white-nose syndrome of bats.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000091956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 10579 {ECO:0000313|Proteomes:UP000091956};
RX   PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA   Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT   "Extreme sensitivity to ultraviolet light in the fungal pathogen
RT   causing white-nose syndrome of bats.";
RL   Nat. Commun. 9:35-35(2018).
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   EMBL; KV460215; OBT98854.2; -; Genomic_DNA.
DR   EnsemblFungi; OBT98854; OBT98854; VE01_03430.
DR   OrthoDB; 1337630at2759; -.
DR   Proteomes; UP000091956; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000091956};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091956};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT   DOMAIN       41    221       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      376    555       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      576    670       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      946   1065       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1109   1295       RNase III. {ECO:0000259|PROSITE:PS50142}.
SQ   SEQUENCE   1388 AA;  154820 MW;  C83F9C4D6C1B8381 CRC64;
     MTSQESTCVA LQDAPANSGA MELSKPSAIP YEQSRLYQLE MFEASMARNT IVVMDTGSGK
     THIAVMRIQA ELERCPPQKR VWFLAPTVAL CEQQCSTLRT NIPYVQTRLL VGSDNVDRWS
     EQRIWDAVLE NVRIVVSTHG VLSDALSHGF VRIEELALLV FDEAHHCAGE HPANKIMKNY
     YHPLLGLKGP DAVPHILGLT ASPVIRSKPS DLEIIERDLN ALCRTPRVHR GELLEHVHPP
     TFVRLAYLSN PSIYGQYTSL ALVSLIAVYT DATNSSTSRD SDDIDLIKET SKVLRELKSF
     CTKANHVYDE LGQWAADYYI KTSIDIWSAA ETKRNGDPFF DNGKRSNAVL ELLLQVHGAS
     SALNSGHPDE TNTTRKVRQL IRFLTSYRDG DLHGIIFVEQ RATVAVLHHL LSVHPMTKGM
     LRCGTFIGTS SFSSRKSSLG DWLSPLEQTD TLDCFRKKDK NFIIATSVLE EGIDISACNI
     VICFNKPPNL KSFIQRRGRA RKRRSIFVLL VPSDDRSLGP QEWGDMEIQM RVEYQKDASK
     RQKLQQLEDT EEHVEGRSNA RFEIKSTGAL LTPETAVAHI HHFCATLPPQ PYVDLQPKFY
     FQESFYGLIT GNVTLPNCVD SSVRTATSGW EWKSERMAKK DAAFQAYVAL YKKGLINDNL
     LPLLLGKDEE VTPDIETRAS VEEVSEIYNP WISIAKSWME PGESLKKKLI SIARPDRPTL
     YLVIVFPQDL PALETFTIYW DNEITYSISI SDTTPISPTD TPFIPIMRQV TSTIFQAVHF
     NRMPTGRDDF LALFIPYIGE GLLRSWLEES AGNLPATEVL NANPNAASYG LIRDQARYAA
     PHIFKETTDD GTIKVTRLPK RRDFLHRSFA SKSDTENEID CSEKPALFLP LESSTVDKLP
     MEYVECSLLI PSIMHRLWRQ ALALDLYNAV FEDQGFLNLD YVITATNAPS ANENSNYQRL
     EFIGDSVLKY LVCVNLYATQ PSWPEGYLSR AKDQAVANSR LSRAALAVGL DRYIVTKTFT
     ARKWSPPYIR DILDAASSPE KRTLSTKVLA DVVEALIGGA FLDRGYEAAA TCISRFLPEM
     PITDPLDIFA RGFGAESVFA PTSLANGHLA DVEHLIGYQF KNRGYLLEAI THPSCEHDSH
     TSSYQRLEFI GDATLDMIVV SFMIDSAPEL SHGRMHLTKT AVVNAGFLAY LCMDSSLEQV
     VTDVALSPNH YSAGFTEVHS SKLVHLCQLM RHQHPEINTA MSSCLERYRK LQPAIASAIA
     HGNEYPWVLL TSLAPAKFLS DIVESIIGAV LIDAGGDLSA CKKVAENIGL IAYLRRILDE
     DIDILHPKNK LGEMSGGQKV EYKLGKEGQE YTCTVEVGGT PIIGVSQGIS QEEVMTQAAY
     MAVVLLGE
//
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