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Database: UniProt
Entry: A0A1B8J6C6_9HELI
LinkDB: A0A1B8J6C6_9HELI
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ID   A0A1B8J6C6_9HELI        Unreviewed;       466 AA.
AC   A0A1B8J6C6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=BA723_01995 {ECO:0000313|EMBL:OBV28500.1}, BKN38_03350
GN   {ECO:0000313|EMBL:OHU84187.1};
OS   Helicobacter sp. CLO-3.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=211 {ECO:0000313|EMBL:OBV28500.1, ECO:0000313|Proteomes:UP000092701};
RN   [1] {ECO:0000313|EMBL:OBV28500.1, ECO:0000313|Proteomes:UP000092701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMC1 {ECO:0000313|EMBL:OBV28500.1,
RC   ECO:0000313|Proteomes:UP000092701};
RA   Greninger A.L., Bateman A., Jerome K., Fang F.;
RT   "Genome sequence of Helicobacter sp. CLO-3.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OHU84187.1, ECO:0000313|Proteomes:UP000179541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLO-3 {ECO:0000313|EMBL:OHU84187.1,
RC   ECO:0000313|Proteomes:UP000179541};
RA   Greninger A.L., Bateman A.C., Fang F., Jerome K.;
RT   "Genome sequence of Helicobacter sp. CLO-3 Fennel-37 strain.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OBV28500.1}.
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DR   EMBL; MAMQ01000116; OBV28500.1; -; Genomic_DNA.
DR   EMBL; MLQN01000008; OHU84187.1; -; Genomic_DNA.
DR   RefSeq; WP_066458184.1; NZ_MLQN01000008.1.
DR   EnsemblBacteria; OBV28500; OBV28500; BA723_01995.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000092701; Unassembled WGS sequence.
DR   Proteomes; UP000179541; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092701,
KW   ECO:0000313|Proteomes:UP000179541};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092701};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN       11    118       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      132    311       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   REGION      379    399       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1B8J6C6}.
FT   ACT_SITE    200    200       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     103    103       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     185    185       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   466 AA;  50129 MW;  67F7008F37F2E5C3 CRC64;
     MHKQLKVALI GVGVVGSSVA QILEKNREII TARTGVEIIV KKGVVRNISK ARNVNIPLTT
     NADEVLYDNE IDVIVELMGG IDEAYKIATI ALNQHKAFVT ANKAMLAYHR YELEKLASTP
     IGFEASVCGG IPIIKALKDG LSANHILELR AILNGTSNYI LSKMTQEGRE FDEALKSAQA
     LGYAEANPSL DINGKDAAHK LLILASLAYG INALPEEILI EGIEHISADD IAFASEFDFC
     IKLLGIAKIT IEGSIELRIH PTMIPTHKLI AKVDGVMNAV SVIGDCVGES VYYGAGAGGN
     ATASSVISDL IEIARGKASE SMLGFETSQE RKLAPKELIK SRYYMRILVC DKPGVLEQIA
     KVLSQNNISV DTFLQRTQEN DKVNNSKANS KTSENLDSGV DSSAACADSR VAGANSRVAG
     ATTEATARMF LTTHTTSEQS IQKAINELKT LPIIKQAPII IRIDDE
//
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