ID A0A1B8JAP4_9HELI Unreviewed; 1022 AA.
AC A0A1B8JAP4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BA723_03030 {ECO:0000313|EMBL:OBV30010.1}, BKN38_00365
GN {ECO:0000313|EMBL:OHU85889.1};
OS Helicobacter sp. CLO-3.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=211 {ECO:0000313|EMBL:OBV30010.1, ECO:0000313|Proteomes:UP000092701};
RN [1] {ECO:0000313|EMBL:OBV30010.1, ECO:0000313|Proteomes:UP000092701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMC1 {ECO:0000313|EMBL:OBV30010.1,
RC ECO:0000313|Proteomes:UP000092701};
RA Greninger A.L., Bateman A., Jerome K., Fang F.;
RT "Genome sequence of Helicobacter sp. CLO-3.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OHU85889.1, ECO:0000313|Proteomes:UP000179541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLO-3 {ECO:0000313|EMBL:OHU85889.1,
RC ECO:0000313|Proteomes:UP000179541};
RA Greninger A.L., Bateman A.C., Fang F., Jerome K.;
RT "Genome sequence of Helicobacter sp. CLO-3 Fennel-37 strain.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBV30010.1}.
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DR EMBL; MAMQ01000022; OBV30010.1; -; Genomic_DNA.
DR EMBL; MLQN01000001; OHU85889.1; -; Genomic_DNA.
DR RefSeq; WP_066453504.1; NZ_MLQN01000001.1.
DR AlphaFoldDB; A0A1B8JAP4; -.
DR STRING; 211.BKN38_00365; -.
DR OrthoDB; 9815825at2; -.
DR Proteomes; UP000092701; Unassembled WGS sequence.
DR Proteomes; UP000179541; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF3; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 2.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU003513};
KW Reference proteome {ECO:0000313|Proteomes:UP000092701}.
FT DOMAIN 44..223
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
FT DOMAIN 274..460
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
FT DOMAIN 570..690
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 742..814
FT /note="Gfo/Idh/MocA-like oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02894"
FT REGION 538..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 110831 MW; EC6BADA2CB7B2B21 CRC64;
MPKTDKTAKL NKTANPEKTP LVLTIIGARP QFVKAKILSL ALERAGIREV ICHTMQHYDY
ELSGVILEEL DLRPVMLSVA WQNVAQVDSG TNPTRSKTTT RNIARLWAMS EAIRREILAK
KPDFVLVYGD TDSTLSGAFA THLCGVPLVH VEAGLRSYDA AMPEERNRVL ADRLATLLCA
PSERARENLA REARDGALRD DARILLSGDV MFDASLYFAK RATPPNITLL DSAKNFAPSR
AISWDEFQKM LASLAESSAI KLDSDISKSD SSARQNTPSN AKTPRFAIAT LHRNTNTDDA
KKLLEILESL AKISWHLPIL FPLHPRTARA LAELESSADL DFDADLGYMA DAALLDSASP
DSTSLDSAPL DSSLRAKLAR IKESAIFFCA PLSYFGMLFC LQRAACVMSD SGGLQKEAYF
FGKPHITLRE NSEYTELSGV HILANTQKSI LAAFARVASE INAQVDSKDL DSGDLDSSLA
KSGLTESSLA DSSARATKPR ATPFGDGNAC DIIASAIWEL YERKGAKMNA RESANAANAA
NAENAENADN SANANKSRAQ SAPASAKRPR FGLIGVGGYI APRHLKAIKE VGGTLICALD
ISDSVGILDS YFPEAAFFTQ EAEFVAFLDA LSGRGEWLDF ISICTPNFLH KHHIAIALNH
GASAICEKPL VLDISSFDEL KALESAAQKR AEKAKIDSAD LLDSGTHPKP RVFGILQLRL
HESIIALKQR ITHELAQNPQ QIYQLRLRYI TPRGRWYGAS WKGDARKSGG IVCNIGVHLF
DMLLFVFGAF ARNEMRGASE TRASGVLELA NARVEWLLSV ESDDLAAHRV ENTQDAEIVE
SSAQNVENTR GNTKNVRGAG FVDSMDSGAA GIDSGAQNPR DMDFLDSGRT GVKALDSASA
LDFASTSKSA NLARTDSHQP PAKKALRILE SIPQDSTSTR DSASTSAPKA LNAQDKAPNP
PSTTPRDMSE PLSFDFSQGF EDLHTKSYQE ILAGMGFGLD DIRACIALIE HISSQINHIN
PD
//
