ID A0A1B8SAF3_9MYCO Unreviewed; 369 AA.
AC A0A1B8SAF3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013190};
DE EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
GN ORFNames=ACT18_21470 {ECO:0000313|EMBL:OBY29723.1}, BST28_21615
GN {ECO:0000313|EMBL:ORA75823.1}, GWR20_18970
GN {ECO:0000313|EMBL:NDJ91202.1};
OS Mycolicibacter kumamotonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=354243 {ECO:0000313|EMBL:OBY29723.1, ECO:0000313|Proteomes:UP000092668};
RN [1] {ECO:0000313|EMBL:OBY29723.1, ECO:0000313|Proteomes:UP000092668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Roo {ECO:0000313|EMBL:OBY29723.1,
RC ECO:0000313|Proteomes:UP000092668};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium kumamotonense strain Roo.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORA75823.1, ECO:0000313|Proteomes:UP000192713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45093 {ECO:0000313|EMBL:ORA75823.1,
RC ECO:0000313|Proteomes:UP000192713};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:NDJ91202.1, ECO:0000313|Proteomes:UP000466523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CST 7247 {ECO:0000313|EMBL:NDJ91202.1,
RC ECO:0000313|Proteomes:UP000466523};
RA Sanchez-Estrada R., Gonzalez-Y-Merchand J.A., Rivera-Gutierrez S.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBY29723.1}.
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DR EMBL; JAACYR010000080; NDJ91202.1; -; Genomic_DNA.
DR EMBL; LFOE01000054; OBY29723.1; -; Genomic_DNA.
DR EMBL; MVHU01000054; ORA75823.1; -; Genomic_DNA.
DR RefSeq; WP_065289474.1; NZ_MVHU01000054.1.
DR AlphaFoldDB; A0A1B8SAF3; -.
DR STRING; 354243.BST28_21615; -.
DR PATRIC; fig|354243.3.peg.4427; -.
DR OrthoDB; 334894at2; -.
DR Proteomes; UP000092668; Unassembled WGS sequence.
DR Proteomes; UP000192713; Unassembled WGS sequence.
DR Proteomes; UP000466523; Unassembled WGS sequence.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08279; Zn_ADH_class_III; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR023921; ADH_Zn_actinomycetes.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR03989; Rxyl_3153; 1.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:NDJ91202.1}; Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 10..366
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 369 AA; 38840 MW; F85E60CB9B9B9F7B CRC64;
MKTIAAVAHA PNQPFEIMEL DLDGPGPGEV LIKFTAAGLC HSDLHVADGD WPNRFPIVGG
HEGSGIIEDV GPGVTKVKPG DHVVCCFIPS CGSCRYCSTG RQNLCDMGAT ILEGCMPDGT
FRFHSGGTDY GGFCMLGTFS ERATVSQHSV VKVDDWLPLE TAVLVGCGVP TGWATANYDG
GVRAGDTVVV YGIGGVGINA VQGAAHAGAK YVVAVDPVEF KRETALKLGA THAFATAEEA
MAKVAELTWG QMADQALITV GDLGEAVTTA AVNTVGKGGT VVIAAMARLE DIDVQVSGTM
LALFGKTIKG TLFGGANPQY DIVRLLRLYD AGQLRLDELV TRRYTLEQVN EGYQDLRDGK
NIRGVIVHR
//
