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Database: UniProt
Entry: A0A1B8SAP1_9MYCO
LinkDB: A0A1B8SAP1_9MYCO
Original site: A0A1B8SAP1_9MYCO 
ID   A0A1B8SAP1_9MYCO        Unreviewed;       275 AA.
AC   A0A1B8SAP1;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:NDJ88810.1};
DE   SubName: Full=Oxidoreductase {ECO:0000313|EMBL:OBY29746.1};
GN   ORFNames=ACT18_21385 {ECO:0000313|EMBL:OBY29746.1}, GWR20_06505
GN   {ECO:0000313|EMBL:NDJ88810.1};
OS   Mycolicibacter kumamotonensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacter.
OX   NCBI_TaxID=354243 {ECO:0000313|EMBL:OBY29746.1, ECO:0000313|Proteomes:UP000092668};
RN   [1] {ECO:0000313|EMBL:OBY29746.1, ECO:0000313|Proteomes:UP000092668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Roo {ECO:0000313|EMBL:OBY29746.1,
RC   ECO:0000313|Proteomes:UP000092668};
RA   Greninger A.L., Cunningham G., Miller S.;
RT   "Genome sequence of Mycobacterium kumamotonense strain Roo.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:NDJ88810.1, ECO:0000313|Proteomes:UP000466523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CST 7247 {ECO:0000313|EMBL:NDJ88810.1,
RC   ECO:0000313|Proteomes:UP000466523};
RA   Sanchez-Estrada R., Gonzalez-Y-Merchand J.A., Rivera-Gutierrez S.;
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBY29746.1}.
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DR   EMBL; JAACYR010000016; NDJ88810.1; -; Genomic_DNA.
DR   EMBL; LFOE01000053; OBY29746.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B8SAP1; -.
DR   STRING; 354243.BST28_19790; -.
DR   PATRIC; fig|354243.3.peg.4410; -.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000092668; Unassembled WGS sequence.
DR   Proteomes; UP000466523; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   NADP {ECO:0000256|ARBA:ARBA00022857}.
FT   DOMAIN          20..258
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            73
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   275 AA;  29975 MW;  C1EB3BC7F200ECAE CRC64;
     MRSVTLNDGN SIPALGFGVY KISPADTEQA VTTALAAGYR HIDTAALYGN EREVGRAVAA
     SGLPRDDVYV VTKVWNADQG YDSTLAAFEK SMGRLGLDVL DLYLIHWPLP ARGKFVDTFR
     ALAHLRDQGR IRSIGVSNFA PEHLKMLIDG AGIVPVVNQV ELHPRFSQAE LREVHSRLGI
     ATEAWAPLGR GSLLSHPTVT EVAQRCGKTP AQVLIRWHIQ LGNIVIPKSV NPERIVSNVE
     VFDFELGTAQ MAAISSLDDG ARLGPDPRTF DYTGR
//
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